Vol 10 Issue 1 April 2022-September 2022

Abstract: The aim of this study was to investigate the prevalence and sources of stress among employees of civil service commission of Bayelsa state, Nigeria. Three objectives and research questions were formulated to guide this study.  A descriptive cross sectional design was adopted for this study with the population of 12,671 employees from different ministries of Bayelsa state. The sample size of 402 was calculated using Taro Yamene method and simple random sampling technique was used to select the sample for the study. The instrument for collect of data for this study was self structured questionnaire titled Prevalence and Sources of Stress Questionnaire (PSSQ) which was validated by three experts. The reliability coefficient of 0.84 of the validated instrument was obtained using Pearson Product Moment Correlation (PPMC). Data collected were analyzed using Statistical Package for Social Science (SPSS) version 25.0 based on the 72.6% return rate of the instrument. The result of this study indicated that the grand mean of 3.30 was greater than the criterion mean of 2.50 depicting that the prevalence of stress among employees was high. Also the result of this study revealed that environmental factors were the sources of stress among employees (grand mean 3.30 vs criterion mean 2.50). The result also indicated that work related factors were the major sources of stress among employees (mean 3.38 vs criterion mean 2.50).  The study concluded that the prevalence of stress among employees was high and the major sources were environmental and work related factors. It was recommended among others that the management of the organization should take the responsibility of employees’ stress conducting stress management and coping programs at the institute level.

Keywords: prevalence, sources, stress, employees, civil service.

Title: Prevalence and Sources of Stress among Employees in Civil Service Commission in Bayelsa State, Nigeria

Author: EBIAMA, Salvation Perefurusowoi

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Vol. 10, Issue 1, April 2022 - September 2022

Page No: 35-42

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Website: www.researchpublish.com

Published Date: 26-May-2022

Abstract: Background: Iron deficiency and malaria are common scourges of children around the world and both conditions may coexist with the other in some individuals, especially in the tropics where malaria is endemic. This study set out to determine the concurrent existence of iron deficiency and malaria among children aged 0 - 5years in Abeokuta, Nigeria.

Method: One hundred and eighteen children clinically assessed and queried for malaria were purposively recruited as subjects. Forty apparently healthy age-matched children were enrolled as the control group. The parameters assessed were packed cell volume (PCV), examination of red blood cell morphology by the thin blood film, malaria parasite by the Giemsa thick blood film and serum ferritin by enzymometric assay. Data were analysed using the chi-squared test to determine the effect of one variable on the other while comparison between two groups was carried out by the Student’s T-test.

Result: The mean PCV of malaria parasite positive subjects (23.90 ± 0.91) was significantly lower than the mean PCV of malaria parasite negative subjects (33.32 ± 1.01) (t =5.72, P<0.05 (0.001)). Both low serum iron level and malaria positivity had significant relationship with the hematocrit of the subjects. Serum ferritin of the patients also showed a significant association with PCV (P<0.05 (0.001)). Children in the age range 1 to 3 manifested the greatest frequency for both low iron levels and malaria positivity.

Conclusion: The co-existence of iron deficiency and malaria among children in the study population is pronounced. Children between age 1 and 3 are at greatest risk of severe iron deficiency and malaria infection in malaria-endemic areas, unless preventive measures are taken.  Low serum ferritin levels among children predisposes to malaria infection such that the lower the serum ferritin level is, the more the susceptibility to malaria.

Keywords: anemia, children, iron deficiency, malaria.

Title: CONCURRENT EXISTENCE OF MALARIA AND IRON DEFICIENCY AMONG UNDER-6 CHILDREN IN ABEOKUTA, NIGERIA

Author: Dr Ayodele O. Ilesanmi, Dr Okezie C. Okamgba, Mrs Rosemary I. Ilesanmi, Kikelomo Oyeleke, Mr Arinze Anyiam, Miss Motunrayo Agbede

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Vol. 10, Issue 1, April 2022 - September 2022

Page No: 25-34

Research Publish Journals

Website: www.researchpublish.com

Published Date: 12-May-2022

Abstract: The ebv have been made two clinical trials in neurooncology based 1-gene therapy 2-neurosurgery molecular PET since the ebv have been built 2 poweful phenomenons which are; tocagene self powered by c-group and self powered by p-group in a recommendatiotions of cis/trans helix loop helix phenomenon of cis/trans carboxyl group based helix loop helix by phosphate group trans in issue based p-group and cis in issue based c-group.

The nitrogenous base (A & G) fully forms the ebv gene seven in one to six ribosomes for a trans proteins subunit like phenylalanine and tyrosine based covalent and ionic bonds in its shape and a Brilliant form.

Keywords: ebv (Epstein Barr Virus); tocagen toca 511 and toca FC (5-fluorocytosine prodrug of 5-fluorouracil); P-group & C-group; brain tumors (GBM & MB); Molecular Imagings (MRI & PET).

Title: Clinical trial Phase - IV For Brain Tumors Based Nanodrugs Via Advanced Molecular Biology & Molecular Neurosurgery Levels a Theory Of gene Engineering Technology {{a clues For New Drug}}

Author: Ahmad Issa Ahmad Funjan

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Vol. 10, Issue 1, April 2022 - September 2022

Page No: 21-24

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Website: www.researchpublish.com

Published date: 10-May-2022

Abstract: Diabetes mellitus is affecting human health all over the world. Both environmental and genetic factors are implicated in its pathogenesis. However, the primary of the factors are still debated. Biochemical mechanism(s) in pancreatic b-cell destructions rendering reduced insulin secretion is postulated to be associated with genetic variation and hence the present proposal was aimed to explore insulin secretory capacity (HOMA-%B), insulin sensitivity (HOMA-%S) and total antioxidant status (TAS) in subjects having parental history of type 2 diabetes mellitus (T2DM) and compared with their negative counterpart.

In this cross-sectional study, 96 normoglycemic subjects were enrolled, among them 48 subjects (case) had parental history of T2DM, rest 48 without parental history of T2DM (controls). Blood glucose was measured by glucose oxidase method. Serum total cholesterol, triglycerides and high density lipoprotein (HDL) cholesterol were measured using Dimension®RxL max clinical chemistry system, and serum low density lipoprotein cholesterol (LDL) were calculated by Friedewald formula. Serum insulin was measured by enzyme linked immunosorbent assay.  HOMA-%B, HOMA-%S and insulin resistance (HOMA IR) were assessed from fasting glucose and insulin using HOMA2 calculator. Total antioxidant status (TAS) was determined by spectrophotometric technique. Data were expressed as median (range) and Mann Whitney U test was performed to calculate statistical difference between groups using GraphPad Prism (6.02). P value < 0.05 was taken as level of significance.

Median (range) of age (years) was 35.0 (30–50) and 36.5 (30–49) in case and controls respectively. Median (range) of fasting and 2hrs plasma glucose (mmol/L) was 4.9 (3.4–7.7) and 5.9 (4.4–10.6) in case and 4.9 (3.5–5.9) and 5.8 (3.8–7.8) in control respectively. Median (range) of fasting serum insulin (μIU/mL) was 16.1 (4.8–53.2) and 13.3 (2.5–46.3) in case and controls which showed statistical difference (p = 0.0134). HOMA-%B was significantly higher in case compared to control [179 (55–381) vs 98 (56–335), p = 0.001]. HOMA %S was significantly lower [49.3 (17.2–95.8) vs 60.2 (15.5–152.9), p = 0.0365] and HOMA IR was significantly higher [2.0 (1.0–5.8) vs 1.7 (0.7– 6.5), p = 0.0365] in case compared to control subjects with BMI ≤ 25 Kg/m². No significance difference was observed in TAS between case and control group [1296 (579 – 2164) vs 1549 (737 – 2690) μmol/L, p = 0.1330].

Data concluded that normoglycemic offspring of T2DM subjects had higher insulin secretory capacity as evidenced by absolute circulating insulin level and HOMA-%B as a measure of pancreatic b-cell secretion suggesting possible influence on heightened expression of related genes. The plausible mechanism(s) are yet to be identified.  Similar levels of total antioxidant status (TAS) in the two groups preclude the oxidative stress involved in the process.

Keywords: Antioxidant status, diabetes, insulinaemic, normoglycemic offspring.

Title: Insulinemic and antioxidant status in normoglycemic subjects with parental history of type 2 diabetes mellitus

Author: Md. Ehsanul Islam khan, Biplob Chandra Shil

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Vol. 10, Issue 1, April 2022 - September 2022

Page No: 15-20

Research Publish Journals

Website: www.researchpublish.com

Published date: 21-April-2022

Abstract: The analysis of semen has been used to diagnose complications associated with reproductive health. It is also worth noting how the same diagnostic procedure is accurate in determining fertility as well as embryo development. The objective of this systematic review was to assess the role of sperm chromatin and sperm maturity to fertility and embryo development. The study included 28 articles from the PROQUEST online database. Several inclusion criteria were used in the selection of relevant articles. The criteria were: (1) the year of publishing, where studies published in 2000 or later were included, (2) studies that applied primary data, and (3) the relevance of the articles as per the independent and dependent variables. The results showed that sperm chromatin and sperm maturity play critical roles in male fertility and embryo development. Regarding the former, the researchers agreed that sperm chromatin plays a major role in the transmission of genetic information. Therefore, the resulting genetic makeup of the embryo depends on the normality or abnormalities of the sperm chromatin. Concerning the latter, this review confirmed a high level of agreement among scholars that a mature spermatozoa is more likely to fertilize than an immature one. The practical implication of this study is the justification of fertility diagnostic tests that examine the sperm chromatin structure and functionality.

Keywords:  Reproductive health, Spermatozoa, Chromatin, Fertility, Embryo development.

Title: The Role of Sperm Chromatin Compactness and Sperm Maturity to Fertility and Embryo Development

Author: Eko Budi Siswidiyanto, Eni Maria Sisca, Ria Margiana, Jefry Albari Tribowo, Pety Narulita, Zakiyatul Faizah

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Vol. 10, Issue 1, April 2022 - September 2022

Page No: 8-14

Research Publish Journals

Website: www.researchpublish.com

Published date: 12-April-2022

Abstract: Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) are genetically heterogeneous disorders of the peripheral nervous system that affect the sensory and autonomic neurons. Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) there are total of 13 different genes are mutated and the disease is transmitted through Autosomal recessive and Autosomal dominant inheritance. Which all 13 genes will cause different types of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) each type of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) has different symptoms according to each type.

Objective: In order to collect information about the Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN)

Methods: A literature review on Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN) related articles and researches

Keywords: Hereditary sensory and Autonomic neuropathy, Hereditary Sensory and Neuropathy, Hereditary sensory and Autonomic neuropathy Type I, Hereditary sensory and Autonomic neuropathy Type IA, Hereditary sensory and Autonomic neuropathy Type IB, Hereditary sensory and Autonomic neuropathy Type IC, Hereditary sensory and Autonomic neuropathy Type ID, Hereditary sensory and Autonomic neuropathy Type IE, Hereditary sensory and Autonomic neuropathy Type II, Hereditary sensory and Autonomic neuropathy Type IIA, Hereditary sensory and Autonomic neuropathy Type IIB, Hereditary sensory and Autonomic neuropathy type III, Hereditary sensory and Autonomic neuropathy Type IV, Hereditary sensory and Autonomic neuropathy Type V, Hereditary sensory and Autonomic neuropathy Type VI, Hereditary sensory and Autonomic neuropathy Type VII, Hereditary sensory and Autonomic neuropathy Type VIII, HSAN, HSAN I, HSAN IA, HSAN IB, HSAN IC, HSAN ID, HSAN IE, HSAN IIA, HSAN IIB, HSAN III, HSAN IV, HSAN V, HSAN VI, HSAN VII, HSAN VIII, HSN, Congenital sensory neuropathy, Familial dysatonomia, Congenital insensitivity to pain with anhidrosis, CIPA, Congenital insensitivity to pain, CIP.

Title: A Literature Review of Hereditary Sensory and Autonomic Neuropathy (HSAN/HSN)

Author: Thanakrit Vasuprasat

International Journal of Healthcare Sciences

ISSN 2348-5728 (Online)

Volume 10, Issue 1, April 2022-September 2022

Page: 1-7

Research Publish Journals

Published Date: 08-April-2022

Website: www.researchpublish.com