Vol 4 Issue 2 October 2016-March 2017

Abstract: Fabry disease is an uncommon, X-linked shortage of α-galactosidase A, affecting approximately 2 - 5 people per 1 million live births. This study as comprehensive review aiming to discuss and overview the clinical symptoms and features of Fabry disease, as well as to emphasizes the complications associated with this familial disease. The Embase, PUBMED/MEDLINE databases were searched for articles published until December 30, 2016. We included in this review every types of studies (reviews, randomized control trails, and systematic reviews) except case reports. The search strategies were through PUBMED/MEDLINE used following Mesh terms to identified relevant studies easily: (fabry disease OR fabry’s disease) AND (Complications, & clinical features. Only Human studies of reviews, meta-analysis, randomized controlled trials published in English language were included. complications of Fabry disease, such as stroke and kidney and cardiac arrest, and poor quality of life, have been revealed by numerous proof based studies, though these complications are not typical among children. The manifestations of this complex disease are multisystemic and progressive. The classic kind is seen in both males and women, although the manifestations are typically less serious in females and disease development is usually postponed compared with males. Keywords: Fabry disease, clinical symptoms, meta-analysis, Human studies, clinical features. Title: Clinical Features and Complications of Fabry Disease Author: Abdulrahman Suhail Al Deiri, Alaa Khaled Safeyah, Ahmed Samir Ragab Abuhamad, Mohammad Fawzi Qusty, Fahad Saleh Alsefry, Rawad Daniel Arja, Thamer Saad shaker alghalbi, Ghalib Nasser Aldawsari, Anwar Saeed Alghamdi International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Acute respiratory distress syndrome (ARDS) which also used to be called Acute Lung Injury (ALI) is a life threatening respiratory problem identified by hypoxemia, as well as rigid lungs; without mechanical air flow most patients would die. The primary purpose of this review is to briefly discuss the diagnostic and treatment options for Acute respiratory distress syndrome (ARDS) in Family practice, the second objective Intended to discuss the pathogenesis and impact of this disease on lung parenchyma, which may give us clear approach to suitable accurate treatment for ARDS. Comprehensive searching strategy through Well-known medical databases (MIDLINE/ PubMed, and Embase) searching articles that published in English language up to December 2016, and discussing the Acute respiratory distress syndrome, especially management and diagnosis of ARDS in Family practice. Furthermore, references list of each article were searched for more eligible papers for present review. It is important to improve diagnostic standards for a specific definition of ARDS and also move it in practice of family medicine. The acute respiratory system distress syndrome (ARDS) is a major cause of acute breathing failure. Its development causes high prices of death, in addition to brief- and also lasting problems, such as cognitive and physical problems. As a result, very early acknowledgment of this syndrome and application of demonstrated restorative interventions are vital to alter the natural course of this devastating entity. In this review article, we define updated ideas in ARDS. Keywords: Acute respiratory distress syndrome (ARDS), Acute Lung Injury (ALI), patients, distress syndrome. Title: Diagnosis and Therapeutic Options of Respiratory Diseases in Family Practice Author: Ruqayyah Ahmed Almutawah, Fatimah Said Alsafwani, Hanan Baqer Al-Msallm, Hassan Mohammed Alessa, Walla sadiq al-hassan, Amal saleh al rashed, Zainab Jaber Al-Mubarak, Zinab Ali Saleh Al Bosrour, Narjes Ali Hassan Al-Rebh, Kawthar Abbas Aldandan, Wejdan hussain alomran International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Our aim from this present study was to evaluate the management approaches of atopic Eczema (AE) in primary care, discussing the diagnostic approaches and steps of treatment procedures. Electronic databases; MEDLINE, EMBASE and The Cochrane Library databases were searched up to January 2017 to identify relevant studies discussing the atopic Eczema (AE) in Primary care, using following Mesh terms: “atopic Eczema” OR “Dermatitis” Combined with “family medicine” OR “Primary care” OR “family Practice”. Family doctor play a main role in the management of AD, be it by referring patients with moderate-to-severe AD for specialized care, giving continuous maintenance care after assessment by experts, or handling patients with mild or extra anecdotal AD themselves. Atopic eczema is a chronic, upsetting skin problem that has a considerable impact on patients and their family members. Education and learning and patient support is therefore essential to its effective management. First-line therapy entails routine application of moisturizers and also periodic use topical steroids to settle flares. Keywords: atopic Eczema (AE), diagnostic approaches, primary care, MEDLINE, family Practice. Title: Approaches of Management of Eczema in Primary Care Author: Eman Essa AlMoaybed, Amal saleh al rashed, walla sadiq al-hassan, Zainab Ali AL-Hassan, RUQAYYAH AHMED ALMUTAWAH, Sakinah Ibrahim Alfadhel, Zainab Abdulmajid Al-Mubarak, Etaa Mohammed Al-Zaher, Zainab lateef alkhabbaz, Fatimah Basim bin alshaykh, Kawthar Abbas Aldandan International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: The main objective of this review was to evaluate several potential GDM predictors with consideration to measures and to determine the extent to which GDM can be predicted in the first trimester in low risk pregnancy. Electronic detailed Search was conducted through following databases; PubMed, Embase, Science direct, searching relevant articles which were concerned with Gestational diabetes mellitus (GDM), we restricted our search to only English published articles up to January 2017, with human subject’s involvement only. furthermore, we search references lists of selected studies for more useful eligible articles to our objective in this review. Glycosylated hemoglobin A1c (A1C) has many benefits over conventional oral glucose tolerance tests (OGTTs) in pregnancy. Ladies with prediabetes by first trimester A1C are considerably more most likely to have GDM, the low sensitivity of an A1C in this variety renders it a poor test to identify females who will develop GDM. Multimarker models combining protein markers and clinical information have the potential to forecast ladies at a high risk of developing GDM. Keywords: Gestational diabetes mellitus (GDM), first trimester, Glycosylated hemoglobin, Multimarker models. Title: Prediction of Gestational Diabetes Mellitus at First Trimester Author: Samah Maiwed Alsawat, Amal Abdulrahman Hunjur, Reem Moutlaq Alsayali, Sara Mohammad Ali Shafei International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Imaging plays a crucial function in the management of patients with brain tumors. The technical improvement of computed tomography (CT) and magnetic resonance (MRI) with the advancement of, brand-new imaging techniques highly enhanced the detection and characterization of brain tumors. This comprehensive review of literature is aimed to discuss the roles of MRI & CT in the diagnosis and evaluation of primary brain tumors, we attempted to discuss the advantage and disadvantage of each modality and which is more effective in this matter. We performed a comprehensive search of literatures among main medical databases; PubMed(MIDLINE), Embase, and science Direct, up to November 2016, to find a relevant article to our study which is discussing the roles of MRI and CT in evaluation of Primary brain tumors. several terms were used in the search through the databases; (MRI, CT, and Imaging), combined with (Brain cancer, primary brain tumors, glioblastomas). We limited our search to English language studies, and only to Human trails. Computed tomography (CT) might be the very first modality employed in a patient presenting with a brain tumor but for one of the most part MRI is the primary imaging modality in brain tumor patients. The function of CT is mostly relegated to emerging imaging in the detection of hemorrhage, herniation, and hydrocephalus but mass effect from brain tumors and calcification within brain tumors such as oligodendrogliomas or menigiomas can potentially be discovered. The main use of MRI-based medical image analysis for brain tumor studies remains in medical diagnosis, patient tracking and treatment preparation, however it could also be useful in clinical trials. Keywords: Computed Tomography (CT), Magnetic Resonance (MRI). Title: Roles of Magnetic Resonance Imaging and Computed Tomography in Diagnosis and Assessment of Primary Brain Tumor Author: Fahad Alhazmi, Fatimah Alzubaidi, Alaa Hussain, Linah Qasim, Mohammed Alzubaidi, Moluk Aldebani, Morooj Aldebani, Yara Bayunus International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Coarctation of the aorta represent 5% -7% of all congenital heart disease (4), with an incidence of roughly 3 cases per 10000 birth. Coarctation may be seen in isolation or with additional heart lesions, such as bicuspid aortic valve, ventricular septal flaw, patent ductus arteriosus, transposition of the fantastic arteries, atrioventricular canal defects, or left-sided obstructive heart problems, consisting of hypoplastic left heart syndrome. Objectives: This review article was aimed to focus in discussing the roles of MRI and Doppler echocardiographic in evaluation and assessment of aortic coarctation. Methods: We conducted a comprehensive computerized search of literature published in English language, up to December,2016. Involving human subjects only, the search was perfumed through the well-known medical databases; Medline/PubMed, and Emabse, searching studies that discussing the roles of MRI and Doppler echocardiographic in evaluation and assessment of aortic coarctation. Results: Doppler echocardiography (DE) is presently the very first imaging modality utilized, demonstrating the location and the intensity of the constriction and has the advantage of estimating noninvasively the pressure gradient throughout the narrowing. Magnetic resonance imaging (MRI) has been acknowledged as the noninvasive imaging method of option for the examination of aortic coarctation before repair surgery. Conclusion: MRI also appears to be the most efficient technique to follow-up patients after coarctation repair work and identify postoperative complications. Echocardiography is the primary imaging modality for evaluation of the heart. Among the major benefits of DE is the ability to measure the gradient throughout the coarctation sector. In addition, the existence of associated hereditary heart and valve abnormalities and heart function can also be examined effectively in a noninvasive way. Keywords: Doppler echocardiography (DE), Magnetic resonance imaging (MRI). Title: Roles of MRI and Doppler Echocardiographic In Evaluation of Aortic Coarctation: Review Author: Atheer Ali Altalhi, Alrumaisaa Ahmad Abdu Daafi, Alaa Ahmed Hamoud Abutaleb, Khadija Mohammed Mashhor, Feddah Mohammed Hakami International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Current study was aimed to discuss and overview the diagnosis and treatment approaches of cystic fibrosis disease (CF), and intended also do highlight the etiology of this disease especially the role of genetics in CF. New treatments are being developed that have the possible to treat the causes, rather than just the symptoms, of CF lung disease. Detailed Search was conducted through Medical Databases; PubMed/ Medline, and Emabse, searching relevant articles discussing the diagnostic approaches as well as treatment of cystic fibrosis, published in English language (as it was restricted applied) up to January, 2017. Moreover, we searched references lists of selected articles for more relevant studies that could been useful in this matter, and we restricted all search studies to human subject only. There is continuing development on treating the downstream elements of CF, such as sputum retention, airway infection, and inflammation, however our improving understanding of the underlying pathophysiology will help us target the early problems in CF, and early arise from studies of a number of substances look appealing. Dealing with the early and root causes of CF will improve results and hopefully also reduce the considerable burdens of treatment. It would be perfect to develop a "single hit" treatment and hence anticipate other treatments, however till that treatment is found, we continue to look for ways to reduce the development of the disease process. Keywords: cystic fibrosis disease (CF), Downstream Elements. Title: Diagnosis &Treatment of Cystic Fibrosis: A Review Author: Rehab Abdallah Yousif Mohammed International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Endometrial cancer, is tumor coming from the endometrium, is the most common gynecological tumor in industrialized nations, and its prevalence is increasing. The aim of this review paper was to focus on discussing and overview the most important aspects of Endometrial cancer which is the most common gynecological cancer, and to specifically discuss the risk factors associated with this type of cancer, diagnostic procedures, and finally treatments approaches. We conducted a comprehensive search for articles published in English up to 2016. Search was performed through following databases; MEDLINE, Current Contents, Web of Science, and PubMed with the terms “endometrial cancer”, “risk factors”, “surgical treatment”, “treatment”, “chemotherapy”, “radiation therapy”, “targeted therapy”. Furthermore, we searched the reference lists of articles identified by this search. We restricted our search to articles with human subjects only. International Federation of Gynecology and Obstetrics staging system of endometrial cancer are reviewed. Endometrial cancer has increased 21% in occurrence because 2008, and the death rate has actually increased more than 100% over the past twenty years. Adjuvant treatment is customized according to histology and stage. Numerous classifications are utilized to assess the threats of recurrence and to determine optimum postoperative management. the incorporation of Adjuvant therapy into treatment programs in endometrial cancer is an amazing area of investigation with the potential to enhance results. Outside of the advancement of a reliable screening test for endometrial cancer, transforming the disease to a chronic state and enhancing progression-free survival. Keywords: Endometrial cancer, Numerous classifications, Risk Factors. Title: Overview of Endometrial Cancer, Risk Factors, Diagnosis, and Treatment Options Author: Zainab Mohammed Al faraj International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: H. pylori infection installs a chronic inflammatory action resulting in an increased cell turnover that, over several years, might lead to an accumulation of mitotic errors, which may lead to gastric cancer by direct or indirect effect. This review aimed to discuss the role of H. pylori in the pathogenesis of gastric carcinoma, and how its most common risk factor on the risk of subsequent neoplastic transformation will also be discussed. We have conducted this review through searching the eligible articles in several databases; PubMed, and Embase, to have more evidence in the association of association between H. pylori and gastric cancer, our search was up to December 2016. And we included every study which discussed the relevant topic that our study aimed to overview. Then we limited our search to English language and only to human trails. Evidence showed a significant association between infection with H. pylori and gastric cancer, as determined by the presence of raised concentrations of IgG antibodies to the organism, and the risk of gastric cancer. The small number of cases, nevertheless, indicates that the magnitude of the odds ratio doubts. However, the association we observed is not likely to be due to opportunity and supports other evidence suggesting a causal association based upon environmental research studies,' medical observations, and what is known about the function of H. Pylori in triggering chronic gastritis. Keywords: Helicobacter pylori, chronic inflammatory action. Title: Helicobacter Pylori and Its Related to Gastric Cancer; Review Author: Dina Saleh Binmahfoodh, Haneen Anees Moumina, Rahaf Mohamad Qari, Ranim Abdulbasit Andijani, Reem Jalal Alsharif, Sara Mohamed Kayal International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: This present review was aimed to overview the Colorectal cancer in primary care in general, and specifically to evaluate the benefits of early diagnosis and roles of family physicians in this manner. We conducted a comprehensive search via Medline and Embase databases, searching for relevant English-language papers studies published up to End of 2016. Papers concerning the colorectal cancer in Primary care, and roles of primary physicians in the early diagnosis of CRC were included in this review. Reference lists of papers and review articles were scanned for further citations Primary care has crucial roles throughout the cancer continuum. Evidence exists for a series of primary care-based techniques to enhance the uptake of cancer testing tests, which require systematic application in practice. The application of cancer diagnostic risk models as well as their impact on situation option and also analysis delay in health care requires further study. Worldwide, there is growing interest in stratifying the care of cancer survivors, but more consideration is needed on just how best to do so on the basis of risk of reappearance in addition to psychosocial and also scientific need and also patient and also company preferences. Keywords: Colorectal cancer (CRC), General physicians (GPs). Title: Early Diagnosis for Colorectal Cancer in Primary Care: An Overview Author: Muteb Khalid Salem Altowairqi, Meshari Abed Abdullah Algethami, Abdulaziz Fahad Al Otaibi, Hussam Saud Alghamdi, Meshari Mesfer Mastour Althobaiti, Hassan Othman Abdullah Alshehri International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: Bronchial Asthma is a life threatening disease and it becomes sever when the humans exposure to factors that induce or exacerbate their illness. Objective: To identify risk factors of adult bronchial asthma in Almadinah Almunawarh. Method: A case-control study was conducted using a specially designed questionnaires to collects data by interviewing 30 cases and 34 control in Almadinah during the period of January 17, 2014 to January 24 m 2014. Result: The majority of cases were older than 25 years, being significantly older than controls ( p-value=0.018 ). Significantly more females in cases than controls ( p-value=0.047 ). Adenoids was also more in cases than controls (p= 0.045 ). Rhinitis affected cases more than control (p = 0.00034). Eczema affected cases more than controls ( p = 0.00042 ). The pollution was significantly associated with asthma ( p = 0.00059 ). Conclusion: According to this study, the risk factors of bronchial asthma are age, sex, occupation, smoking, adenoids, rhinitis, dust in environment, and animal around patients, Eczema, sport practice, pollution and allergic food. Keywords: Adult Bronchial Asthma, Eczema, sport practice, pollution and allergic food. Title: Risk Factors of Bronchial Asthma in Almadinah Almunawarh Author: Molammed Balla, Abdullah S Alrowithi International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: This current review was aimed to evaluate the screening strategies and treatment approaches for migraine headache attacks, also to discuss the risk factors associated with this serious neurological disorder. Targeted detailed search was conducted through databases; PubMed/Midline, and Embase, for these articles disusing the migraine from different aspects and mostly diagnostic procedures and treatment options, with human subjects published up to end of 2016, We restricted this search to only English language published articles. To be able to approach the precise therapy choice a comprehensive medical diagnosis has to be executed among patients believed with migraine headache. This review stresses the functional therapy of migraine headache in addition to the development that has actually been made in specifying migraine pathophysiology as well as in developing new particular treatments. There is overlapping reaction to therapy: non-steroidals, triptans, dihydroergotamine, as well as the anti-emetic dopamine-antagonists may play a restorative role for every of these acute headaches. Keywords: Evaluate The Screening Strategies And Treatment Approaches, Migraine Headache Attacks. Title: Screening Methods, And Treatment Approaches of Migraine: An Overview Author: Abdullah Khalid Alsuwat, Ahmed Masad Alzaidi, Abdullah Ayed Al_Nefaie, Abdullah Mutlaq Alotaibi International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: This review study summarizes the major studies that have investigated the procedure, indication, benefits, and outcomes, of coronary artery bypass graft surgery (CABG). This article intended to overview the GABG from different aspects, that could it easier for the reader to see many aspects in one article. We conducted computerized searches of Medline, Google scholar, and Embase, we reviewed the English language literature that was published up to November, 2016. CABG provides considerable enhancement in survival and lifestyle for properly chosen patients with multivessel coronary artery disease. Those with advanced coronary artery disease, left ventricular dysfunction, or diabetes are particularly most likely to take advantage of CABG. Medical care physicians, internists, and cardiologists play a key role in the patient choice and referral procedure. Ongoing research might incrementally enhance the CABG procedure, the biggest improvements in results are most likely to be understood by appropriately picking patients to undergo CABG. Keywords: Cardiologists Play, Coronary Artery Bypass Graft Surgery (CABG). Title: Coronary Artery Bypass Graft, Indication, Benefits, and Outcomes: Overview Author: Ziyad Mohammed Ziyad Alrajhi, Awad Hasan Alamri, Anwar Khalid Boudal, Haneen Mohammed M Alghamdi, Dr. Wafaa Hamad M Alameer, Dr. Ahmed Abdulaziz Ali Haider, Mustafa Baker Alshareef, Marwa Thani Hawsawi International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: This current study was aimed to discuss and overview the Pediatric cardiopulmonary arrests (CPAs) from different perspectives, we intended to review the epidemiology of CPAs, prehospital management approaches, and other methods of treatment. Comprehensive review was performed by searched most known databases; MEDLINE, EMBASE, and CENTRAL. We searched the English literature focusing in discussing Pediatric cardiopulmonary arrests (CPAs), that were published up to December, 2016. In addition, reference lists of relevant identified study and included articles were also searched for more eligible articles that could support our review. End results from pediatric heart attack and also CPR seem to be enhancing. The advancement of medical practice to incorporate the pathophysiology and timing, strength, period, and also variability of the hypoxic-ischemic disrespect could bring about even more patient-specific and also time-specific goal-directed treatment as well as better outcomes. By tactically focusing therapies to details phases of heart attack as well as resuscitation and also to developing pathophysiology, there is excellent promise that critical care interventions will blaze a trail to much more successful cardiopulmonary and cerebral resuscitation in children. The 2005 ILCOR guidelines emphasize good-quality CPR in the pre-hospital and also medical facility setups. By-stander CPR enhances results but is done in a minority of patients, identifying a should enhance CPR education in general population. Treatment of the post-CA syndrome stays generally helpful; hypothermia must be taken into consideration in comatose patients. Advanced neuromonitoring and also novel treatments are needed for the following innovation. Keywords: Pediatric cardiopulmonary arrests (CPAs). Title: Pediatric Cardiopulmonary Arrest Author: Zainab Abdrabalredh Busaleh, Hamza Ali Busaleh, Faisal Abdullah Alshammari International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

Abstract: This review study was aimed to discuss the Peptic ulcer disease (PUD) from different aspects, mostly will try to emphasizes the risk factors associated with PUD, and also pathogenesis, in Addition to aid the diagnostic approaches, and finally the treatment options for PUD. A comprehensive detailed search was conducted to identify literature discussing Peptic ulcer disease (PUD) general population, published up to November 2016. Searching was conducted through; PubMed, EMBASE and the Cochrane library databases, were searched for studies of human subjects only. Furthermore, references found in identified articles were manually searched for more relevant studies to be included in this review. Peptic ulcer disease is an issue of the gastrointestinal tract defined by mucosal damage secondary to pepsin and gastric acid secretion. It normally happens in the stomach and proximal duodenum; less frequently, it occurs in the lower esophagus, the distal duodenum, or the jejunum. Testing for and eliminating H. pylori infection in patients is suggested prior to starting NSAID treatment, and for those currently taking NSAIDs, when there is a history of ulcers or ulcer complications. Comprehending the pathophysiology and best treatment strategies for non-NSAID, non-H. pylori-associated peptic ulcers presents a challenge. Keywords: Peptic ulcer disease (PUD), diagnosis and treatment. Title: Overview of Peptic Ulcer Disease, Etiology, Diagnosis and Treatment Author: Azhar Eisa Dallak, Rafan Abdulrhman Madkor, Albaraa Mohammad Madkhali, Manal Ibrahim Bahkali, Tayseer Hasan Hakami, Abadi Abdullah Hakami, Rbouah Mohammad Ayashi, Abdullatif Alhassan Fathi, Sawsan Mohammed Abu Hadi, Ebtehal Zaid Alqahtani, Ali Khudaysh Muqri, Omar Abdulaziz Madkhali International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals