Vol 13 Issue 2 April 2025-June 2025

Abstract: The impact of logotherapy intervention on student’s perceived academic performance and stress levels was investigated using quantitative methodology, among students in Texas, ages 18 to 60 with particular attention to subgroups facing unique challenges, including work-study and single-parenthood. A total of (N = 200) participants were randomly assigned to either an intervention group (n = 100) receiving logotherapy-based support or a control group (n = 100) receiving no intervention for three, five-weeks sessions from December 2024 to March 2025. Academic performance was measured using self-reported GPA, while stress levels were evaluated using a Modified Preferred Stress Scale (PSS – 10) before and after the intervention. The results demonstrated a statistically significant improvement in academic performance for the intervention group (M = 3.5, SD = 0.4) compared to the control group (M = 2.8, SD = 0.5), [t(198) = 8.52, p < 0.001], with a large effect size (Cohen’s d = 1.54). Similarly, stress levels were significantly lower among students who received the intervention (M = 4.2, SD = 1.3) than those who did not (M = 7.8, SD = 1.6), [t(198) = -13.21, p < 0.001], with a large effect (Cohen’s d = 1.86). Two-way ANOVA analyses further revealed that work-study and single-parent students experienced amplified benefits, with significant interaction effects indicating that the intervention was especially effective for these subgroups. These findings suggested that logotherapy not only enhances academic outcomes but also provides critical emotional resilience, particularly for students managing complex life responsibilities. The study supports the integration of logotherapy-based interventions into academic support services to improve educational persistence and psychological well-being among diverse student populations.

Keywords: Logotherapy, Academic Performance, Stress levels, Meaning-Centered Motivation.

Title: The Impact of Logotherapy on Students’ Perceived Academic Performance and Stress Levels

Author: Dr. David Augustine Bull

International Journal of Life Sciences Research

ISSN 2348-313X (Print), ISSN 2348-3148 (online)

Vol. 13, Issue 2, April 2025 - June 2025

Page No: 11-31

Research Publish Journals

Website: www.researchpublish.com

Published Date: 14-April-2025

Abstract: Background: Growing evidence suggests the involvement of angiotensin-converting enzyme 2 (ACE2) in lipid metabolism and cardiovascular homeostasis. Genetic variations in ACE2 have been linked to metabolic disorders, including dyslipidemia, which is a hallmark of type 2 diabetes mellitus (T2DM). However, the association of ACE2 polymorphisms and dyslipidemia in T2DM patients, particularly in Iraqi populations, remains underexplored. 

Aim: This study aimed to investigate the association of ACE2 gene polymorphisms (rs2285666 and rs4646142) with dyslipidemia in Iraqi patients with T2DM, stratified by sex. 

Methods: A case-control study was conducted involving 463 T2DM patients (222 women and 241 men). Based on serum lipid profiles, participants were stratified into dyslipidemic (cases) and non-dyslipidemic (control) groups. Genotyping of ACE2 polymorphisms was performed using PCR-based methods, and serum ACE2 levels were quantified using ELISA.

Results: The AA genotype of rs2285666 SNP was significantly associated with dyslipidemia in women (OR = 3.19, 95% CI = 1.31–7.78, p = 0.01), while the A allele was associated with dyslipidemia in men (OR = 2.36, 95% CI = 1.27–4.39, p = 0.006). High ACE2 levels, elevated atherogenic indices, and adverse lipid profiles were observed in carriers of the A allele. No significant association was found for rs4646142 SNP. 

Conclusion: The rs2285666 SNP was associated with dyslipidemia in Iraqi T2DM patients, with sex-specific differences in risk. The ACE2 variants may contribute to dyslipidemia pathogenesis in T2DM and highlight the potential for personalized risk stratification and therapeutic targets.

Keywords: ACE2, rs2285666, rs4646142, Dyslipidemia, T2DM, Association.

Title: Association of ACE2 Gene Polymorphisms (rs2285666 and rs4646142) with Dyslipidemia in Iraqi Patients with Type 2 Diabetes Mellitus A Sex-Stratified Analysis

Author: Ali B. Abulrazzaq, Ibrahim Rahem Jassim Al-Aadily, Maha Radhi Abass, Majid Kadhum Hussain

International Journal of Life Sciences Research

ISSN 2348-313X (Print), ISSN 2348-3148 (online)

Vol. 13, Issue 2, April 2025 - June 2025

Page No: 1-10

Research Publish Journals

Website: www.researchpublish.com

Published Date: 04-April-2025