Vol 12 Issue 4 October 2024-December 2024

Abstract: Background: Alcoholism has been associated with brain damage especially in distinct brain regions such as the prefrontal cortex. Aim: To explore the astrocytes and neuronal cell population of the Prefrontal Cortex treated with tannic acid (TA) following ethanol-induced prefrontal cortex toxicity using standard GFAP and NeuN immunihistochemisty protocols. Methodology: Thirty six (36) adult male wistar rats (160g-240g) were assigned into six (6) groups (A to F) of 6 rats each. Group “A” (untreated negative control) received daily doses of distilled water at 6ml/kg/bwt while Group “B” (alcohol control group) received daily doses of 6g/kg/bwt of 40% ethanol only. Group “C, D and E” received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 200mg/kg/bwt, 100mg/kg/bwt and 50mg/kg/bwt of TA respectively. Group “F” (positive control group) received daily doses of 6g/kg/bwt of 40% ethanol co-administrated with 335mg/kg/bwt of Vitamin-E. All treatments were oral and lasted 14 days. The animals were sacrificed under intraperitoneal ketamin/thiopental sodium as anaesthesia after 24 hours of fasting. Brain tissues were quickly but carefully removed and fixed in 10% formal saline. The prefrontal cortex was grossed and processed according to standard protocols, sectioned at 5μm thick for standard GFAP and NueN immunohistochemistry studies. Result: TA, particularly in higher doses, offers comparable, if not superior neuroprotective effects than Vitamin-E. Across different dosages, TA mitigated ethanol-induced neuronal loss and promoted neuronal survival and differentiation in the prefrontal cortex. Conclusion: Tannic acid posed as a potential therapeutic agent in treating ethanol-induced neurotoxicity, with efficacy demonstrated even at lower doses.

Keywords: Tannic acid, Ethanol toxicity, Prefrontal Cortex, immunohistochemistry, Wistar rats.

Title: NEUROPROTECTIVE EFFECTS OF TANNIC ACIDS ON ASTROCYTES AND NEURONAL CELL POPULATION IN NEURAL CREST CELLS OF THE PREFRONTAL CORTEX FOLLOWING ETHANOL-INDUCED PREFRONTAL CORTEX TOXICITY; AN IMMUNOHISTOCHEMICAL STUDY

Author: Christian Chiemeka Ozor, Chike Anibeze, Elizabeth Finbarrs-Bello.

International Journal of Thesis Projects and Dissertations (IJTPD)

Vol. 12, Issue 4, October 2024 - December 2024

Page No: 14-22

Research Publish Journals

Website: www.researchpublish.com

Published date: 16-December-2024

Abstract: This mixed method study explored the Impact of Online Gig Economy on the Satisfaction of Workers, focusing on the level of impact on the career, health, schedule and economic aspect and the level of their satisfaction in terms of job, income, career development and overall satisfaction. Data were gathered online through Focus Group Discussion and questionnaire with 406 respondents in the Philippines servicing various niches. It also examined the influence and relationship of the Impact of Online Gig Economy on the Satisfaction of Workers using linear regression analysis. Results showed that respondents have a high level of satisfaction from the very high level of career growth and economic advancement opportunities they enjoyed compared to traditional employment. However, workers also experienced high level of occupational health issues from lack of sleep, sedentary lifestyle, developing unhealthy eating habits and isolation, high extent of operational difficulties such as the need for stable supply of electricity and internet connection and the lack of representation, tax/employment classification and government protection, and high extent of professional challenges in obtaining clients and upskilling and learning software usage, social media marketing and digital platforms.  The results further indicated a moderate positive correlation between the Level of Impact of Online Gig Economy and the Level of Satisfaction of Workers. Furthermore, the very high level of Impact of Online Gig Economy on the career and economic aspect significantly influence the high level of satisfaction of workers, but there may still be unaccounted factors influencing it.

Keywords: Online Gig Economy, Online Freelance Workers, Virtual Assistants, Impact, Satisfaction.

Title: Impact of Online Gig Economy and Satisfaction of Workers: A Mixed Method Design

Author: Marlen P. Yumang

International Journal of Thesis Projects and Dissertations (IJTPD)

Vol. 12, Issue 4, October 2024 - December 2024

Page No: 1-13

Research Publish Journals

Website: www.researchpublish.com

Published date: 18-November-2024