Abstract: Anaphylaxis is a rapid-onset, multisystem hypersensitivity reaction with potentially fatal outcome. Clinically, anaphylaxis most frequent manifestations are cutaneous. Type A anaphylactic Hypersensitivity reaction is immediate type of reaction that occurs due to release of IgE antibodies and mediators that cause various lesions.
A 26 year old female Patient who was a known case of seizure disorder was presented with chief complaints of burning micturition and abdominal pain due to urinary tract infection and lower urinary tract symptoms. Injection tazomac was started to treat Urinary Tract Infection but after Ist dose patient developed Sudden fall in BP, tachycardia, weak thready pulse, seizures, altered sensorium, angioedema, eye edema, pedal edema as hypersensitivity reaction therefore injection was immediately stopped and specific treatment of adrenaline, dopamine, levocetirizine, pheniramine, lorazepam and phenytoin was started to treat symptoms. Patient was shifted to ICU, ECG was done, which suggest ECG changes, trop – I was done which was suggest Acute Ischemic Changes, cardiology reference was done. The Patient was well treated and discharged in satisfactory conditions, and was adviced allow up in cardiology OPD.
Allergic reactions to antibiotics may occur in the form of immediate or delayed hypersensitivity. Immediate reactions are usually immunoglobulin (IgE-mediated whereas non-immediate or delayed-type hypersensitivity reactions are usually non-IgE or T-cell mediated. Healthcare professionals should keep the record of medication history that to which drug patient is allergic so that it can be avoided in future and in case of any ADR it should be reported.
Keywords: Lower urinary tract symptoms(LUTS), Tazomac(Piperacillin+ Tazobactam), Adverse drug Reaction (ADR).
Title: A CASE REPORT ON PIPERACILLIN AND TAZOBACTAM INDUCED ANAPHYLACTIC REACTION INCLUDING SEIZURES IN PATIENT OF URINARY TRACT INFECTION
Author: Devesh Joshi, Rashi Bahuguna, Madhu Lata Rana
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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