Abstract: Migraine is one kind of chronic neurological disorder in which one experience reversible type of headache with neurological and systemic symptoms. The main symptoms includes fear of noise (phonophobia), sensitivity to light (photophobia), cutaneous allodynia, and some symptoms related to gastrointestinal tract (GIT) which includes emesis and nausea. The pain of migraine is not immediately experienced rather precursory symptoms can be experienced hours and days before the inception of pain. As per aspects of its pathophysiology the migraine attack can be split up into phases: the premonitory phases, the aura phase, headache phase and postdrome phase, respectively. The present studies involves study of pathology behind migraine attack along with role of nitric oxide synthase enzyme and also covers the detailed description of few reported molecules for inhibiting the action of nitric oxide synthase. We believe that this will help the in successfully design of new analogues.
Keywords: Amino acids; Headache; Nitric oxide synthase; Migraine; Peptides.
Title: A REVIEW ON REPORTED NITRIC OXIDE SYNTHASE INHIBITORS FOR TREATMENT OF MIGRAINE
Author: Yaksh Mahajan, Pankaj Wadhwa, Anuradha, Vanktesh Kumar
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
