Abstract: Coronary artery disease (CAD) is a multifactorial disease with no known definite cure, but preventable and treatable. Many studies have linked excess generation of reactive oxygen species (ROS) with cellular damage and CAD. No systematic studies were conducted to evaluate the role of oxidative stress and antioxidant status on CAD severity. Hence we have undertaken this study. One hundred and twenty four angiographically proved CAD patients were included in this study. CAD severity was assessed by angiography. The patients with 0 vessel disease were taken as control to study the correlation of lipid peroxidation with CAD severity. Lipid peroxidation product, Malondialdehyde (MDA), antioxidants such as Super Oxide Dismutase (SOD), Glutathione (GSH) and Ascorbic acid of all patients were estimated in the serum. Our results revealed that there was higher lipid peroxidation with CAD severity as indicated from lower values of MDA and higher values of SOD in 0 vessel disease compared to single vessel, double vessel and triple vessel disease patients (p<0.05). The severity of CAD is closely related to increased lipid peroxidation and decreased antioxidants status as indicated by the MDA and SOD levels.
Keywords: Coronary artery disease (CAD); Reactive oxygen species (ROS); CAD Severity
Title: A Study to Evaluate the Severity of Coronary Artery Disease (CAD) In Relation To Oxidative Stress and Antioxidant Status
Author: Dr. Chithra V, Supriya Simon A, Anoop Vijayan, Rajan Joseph Manjuran
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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