Abstract: Diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels.1 Proteinuria has been recognized as one of the earliest signs of renal function deterioration in diabetes mellitus. In the present study, an attempt has been made to establish the PCI in random urine samples, as a convenient, quick and reliable method for the estimation of proteinuria in diagnosing and monitoring diabetic nephropathy. An attempt has also been made to determine the optimal cutoff value of PCI for the prediction of significant proteinuria. This study signifies the role of urinary PCI in detecting even a minor increase in the protein excretion in a random urine specimen. Total of 50 samples were collected from the IPD and OPD patients, 25 patients aged 25 to 65 years, who were diagnosed as diabetics and were confirmed by the estimation of fasting serum glucose (>126 mg/dl). 25 normal healthy subjects, age and sex matched with the diabetic patients, were selected as the Controls. The comparison of urinary protein, urinary creatinine and urinary protein:creatinine index(PCI) between control and study group was analyzed using unpaired “t”-test. . The urinary protein levels were significantly increased, urinary creatinine levels were decreased and urinary protein:creatinine index was significantly higher in diabetic patients as compared to the control group. The present study suggests that random urinary PCI can be a good predictor of significant proteinuria in long term suffering patients of diabetes mellitus during diabetic nephropathy. This test could be a reasonable alternative to the 24-hour urine sample collection for the detection of significant proteinuria in diabetes mellitus patients.
Keywords: Diabetes mellitus, Protein:creatinine index, Proteinuria.
Title: ESTIMATION OF URINARY PROTEIN CREATININE INDEX IN DIABETES MELLITUS PATIENTS WITH MORE THAN 10 YEARS OF DIABETIC HISTORY
Author: Gazallah Jabeen, Ashutosh Kumar
International Journal of Civil and Structural Engineering Research
ISSN 2348-7607 (Online)
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