Abstract: Appropriate clinical care of hematologic malignancies depends on timely and accurate diagnosis. The category of cancers known as acute leukemias is diverse, with each disease having a unique clinical presentation, prognosis, and preferred course of therapy. The majority of morphologic and cytochemical characteristics were used in historical categorization systems, but currently, immunophenotypic, cytogenetic, and molecular data are included to construct clinically useful diagnostic classifications. When combined with morphologic evaluation, multiparameter flow cytometry quickly and precisely determines antigen expression profiles in acute leukemias, which frequently supports a specific diagnosis or a limited differential. Because numerous recurrent molecular or cytogenetic abnormalities are linked to distinctive immunophenotypic characteristics, flow cytometry is a crucial tool for guiding additional testing.
Even within a single acute leukemia subtype, the identification of certain antigens may have prognostic or therapeutic significance. The immunophenotypic fingerprint of a leukemia after first diagnosis serves as a helpful guide to track treatment response, minimal residual disease, and recurrence.
Objective: To evaluate flowcytometry role in distinguishing acute myeloid leukemia (AML) from ALL using CD markers.
Material and methods: This is retrospective study conducted in King Fahad Medical City in Riyadh city, in the period between November to December 2019 on patients with acute leukemia diagnosis.
Conclusion: Accurate acute leukemia diagnosis and categorization depend on immunophenotypic analysis. Multiparameter flow cytometry offers a quick and efficient way to gather these data, as well as prognostic data and a technique for assessing minimal residual illness.
Keywords: Appropriate clinical care, accurate diagnosis, leukemias, cytochemical characteristics.
Title: Aberrant antigen expression in acute leukemia: A single center study in Saudi Arabia
Author: Yasir Awad Ahmed, Abdulrahman Abdulkhalig Alshamrani, Abdullah Hussain saeed alomari, Ali Ahmed Yahya Motmy, Abdulrahman Saleh Suliman
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 10, Issue 4, October 2022 - December 2022
Page No: 8-14
Research Publish Journals
Website: www.researchpublish.com
Published Date: 17-October-2022
