Abstract: Theophrastus Phillipus Auroleus Bombastus von Hohenheim (1493–1541) is credited with the classic toxicology maxim, "Alle Dinge Sind Gift und nichts ist ohne Gift; allein die Dosis macht, dass ein Ding kein Gift ist." which translates as, "All things are poisonous and nothing is without poison; only the dose makes a thing not poisonous." This is often condensed to: "The dose makes the poison". The goal of toxicity assessment is to identify adverse effects of a substance. Adverse effects depend on two main factors: routes of exposure (oral, inhalation, or dermal) and dose (duration and concentration of exposure). To explore dose, substances are tested in both acute and chronic models. Generally, different sets of experiments are conducted to determine whether a substance causes some forms of toxicity. Methanol is an industrial chemical used after 1800s. It is a toxic. This chemical are used to produce biodiesel and also used in ethanol manufacturing industries as a denaturant additive. In the 2010, the American Methanol Institute (AMI) evaluation stated the methanol demand may be reach up to the 882 million gallons per year. In the present study Methanol was selected as Toxicant on fingerlings of freshwater fish Cirrhinus mrigala to understand the alterations in Alkaline Phosphates after acute exposure. It was observed that Alkaline Phosphates decreased as the dose component was increased.
Keywords: Toxicant, Methanol, Alkaline phosphates activity, Freshwater fish.
Title: Alterations in the Alkaline Phosphate Activity of Freshwater Fish Cirrhinus mrigala Exposed to Methanol
Author: Madhav Bhilave
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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