Abstract: One of the natural ingredients that have the potential to serve as such an alternative is mangosteen peel. Mangosteen peel is a shell that is discarded by consumers or can be called agricultural waste. So far, the utilization of mangosteen peels is only for tanning leather, traditional medicine, and the making of anti-rust substances and textile dyes. The utilization of mangosteen rind for treatment in Indonesia is still not much, especially as a wound healing. Therefore, researchers are interested in exploring the wound-healing effects of mangosteen peel extract. This experimental laboratory study used a complete randomized design with a post-test-only control group design pattern. The experimental animals used in this study were 32 male Wistar rats, physically healthy, 2-3 months old, with body weight between 200-250 grams. The sample size was determined by the Federer formula, namely: (t - 1) (r - 1) ≥ 15, and the minimum sample size for each treatment was 16 rats. The results showed a significant relationship between the number of fibroblast tissue per visual field in Wistar rats after tooth extraction with the administration of Ethanol Mangosteen fruit peel (Garcinia mangostana L) 50% concentration and Ethanol Mangosteen fruit peel (Garcinia mangostana L) 100% concentration, p=0.008 (p<0.05). In conclusion, Ethanol Mangosteen fruit peel (Garcinia mangostana L) 50% and 100% are effective in accelerating wound healing time after tooth extraction of Wistar rats. Ethanol Mangosteen fruit peel (Garcinia mangostana L) 100% is more effective than Ethanol Mangosteen fruit peel (Garcinia mangostana L) 50% in accelerating wound healing time after tooth extraction of Wistar rats because the flavonoid content in Ethanol Mangosteen fruit peel (Garcinia mangostana L) 100% which helps accelerate wound healing is higher than Ethanol Mangosteen fruit peel (Garcinia mangostana L) 50%.
Keywords: Garcinia mangostana L, Wound healing, Tooth Extraction, Ethanol.
Title: Analysis of Wound Healing After Tooth Extraction from Ethanol Extract of Mangosteen Fruit Peel (Garcinia Mangostana L.) In Wistar Rats (Rattus Norvegicus)
Author: Wang Xiaofang
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 97-103
Research Publish Journals
Website: www.researchpublish.com
Published Date: 27-March-2023
