Abstract: Turmeric is herbs used as an food adjunct in India, reported to prevent oxidation of fats and oils but the cooking at high temperature is a common practice and the thermal stability of turmeric and its retention of the potential activity are not yet clear. It is recommended in anticancer treatment that they are antiangiogenic through multiple interdependent processes. Angiogenesis plays an important role in the development of cancer and excessive angiogenesis is reported to be related to many diseases. Anti-angiogenic therapy is promising agent for cancer therapy. The scientific validation of anti-angiogenic effects of heat treatment given Standard Turmeric Extract (STE) was done in zebrafish in-vivo angiogenesis model. It was observed that the STE molecules inhibited the growth of intersegmental vessel (ISV) of zebrafish embryos in a dose dependent manner, as observed by red blood cells (RBC) staining assay. This study reveals the scientific validation of the potential anti-angiogenic effect of STE supports its use in food preparations as a herbal adjunct for prophylaxis of diseases occur through angiogenesis.
Keywords: Thermal Process - Standard Turmeric Extract (STE)- ant iangiogenesis- Zebra fish.
Title: ANTI-ANGIOGENIC ACTIVITY ANALYSIS OF THERMAL PROCESSED TURMERIC EXTRACT IN VIVO IN DEVELOPING ZEBRA FISH EMBRYOS (DANIO RERIO)
Author: A. Mangalagowri, V.Perasiriyan, A.N. Thamilarashi
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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