Abstract: Background: Antituberculosis drug-induced acute liver failure (ALF) is quite common. However, factors predicting its development are still controversial. Objective: the aim of this study is to evaluate and investigate the anti tuberculosis therapy induced acute liver failure by going through the literature review. Methodology: we conducted our literature search for similar previous studies mainly in Medline (PubMed), the studies were included which are concerning the Antituberculosis drug-induced acute liver failure (ALF) up to December 2015. Result: studies it has been observed that the risk of ATT-induced acute liver failure ALF increases recently, with no significant correlation of age with ATT-induced hepatitis was found, although it has been reported that women are more prone to develop ATT-induced ALF. Conclusion: Standard antituberculous therapy including isoniazid, rifampin, ethambutol, and pyrazinamide is widely used for the treatment of active tuberculosis. Its most important side effect is acute liver failure.
Keywords: anti tuberculosis therapy, drug-induced, acute liver failure (ALF).
Title: Anti tuberculosis Therapy (ATT) Induced Acute Liver Failure (ALF)
Author: Mohammed Hisham Al-kulak, Saga Eid Sadek Omar ElKhatib, Ibrahim Rashed Ibrahim Albadi, Rakan Nizar Ahmed Wizza, Jameel Jamal Frhat
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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