Abstract: The role of radiation biology has acquired greater relevance and significance in addressing the health issues. Radiation is often used to treat malignant tumours, or in combination with surgery. Despite the advantage of radiotherapy and improvements in techniques, many patients experience moderate to severe side effects. Adhatoda vasica, an evergreen, gregarious, stiff and perennial shrub of family Acanthaceae has been used as herbal medicine in treating a wide variety of diseases in India. The objective of the present study was to evaluate the anti-ulcer effect of Adhatoda vasica extract on gamma –radiation induced gastric lesions in mice. Mice showing no signs of morbidity were divided into four groups (i) control (ii) Adhatoda extract treated mice (900mg/kg body weight) (iii) Irradiated mice (5gy) (iv) Adhatoda extract treated and irradiated mice. Adhatoda extract was administered orally to the animals (900mg/kg body weight) for a period of 30 days. After 10 days of extract administration mice were irradiated with 5Gy γ-rays. Mice were sacrificed by cervical dislocation and stomach was excised on 10, 20 and 30 days. Stomach was opened along the greater curvature. It was rinsed with water to remove gastric contents and blood clots. Stomach was then examined by a 10×magnifier lens for the assessment of ulcers. Control group and Adhatoda extract treated mice stomach revealed normal and healthy gastric architecture. Irradiated group of mice showed multiple haemmoragic spots and erosions during different stages of investigation. The mice group pretreated with extract and then irradiated showed significant ulceration inhibition providing protection to stomach.
Keywords: Gamma radiaton, Anti-ulcer effect, Hemorrhagic spots, Ulceration inhibition.
Title: ANTI-ULCER ACTIVITY OF ADHATODA VASICA EXTRACT ON GAMMA RADIATION INDUCED GASTRIC LESIONS IN MICE
Author: ANUPAM PUNDIR, SUSHMA SHARMA
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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