Abstract: Bacterial infections associated with metallo-beta-lactamase (MBL) production are often difficult to manage with existing antibiotics. This is as a result of the broad antibiotics hydrolytic spectrum of metallo-beta-lactamases which are known to hydrolyze all beta lactams except the monobactam antibiotics. this investigation was carried out to assess the antibiogram of metallo-beta-lactamase (MBL) producing bacteria from selected sachet water samples sold in Calabar Metropolis. Isolates from a previous study confirmed to harbour the blaIMP and blaNDM genes were subjected to antibiotics susceptibility testing following Clinical Laboratory Standard Institute guidelines. The antibiotics resistant spectrum of the MBL producing isolates were: Plesiomonas shigelloides strain 187 (OFX-CN-AU-CH-CAZ), Enterobacter cloacae strain S20504 (OFX-CN-AU-CH-S-CAZ), Photobacterium ganghwense strain ZR07 (CAZ), Bacillus licheniformis strain 60 (OFX-CN-AU-CH-S-AZT-CAZ), Klebsiella pneumoniae strain DSM 30104 (OFX-CN-AU-CH-S-SXT-CAZ), Plesiomonas spp strain TIL_TAL_1 (OFX-PEF-CN-AU-S-SXT-AZT-CAZ), Comamonas testosterone strain 1 (OFX-CN-AU-S-SXT-AZT-CAZ), Enterobacter sacchari SP1 (OFX-PEF-CN-AU-AM-CH-S-AZT), Acinetobacter soli strain MBR7 ( CAZ), Photobacterium ganghwense strain ZR07 (AZT-CAZ). The multiple antibiotics resistance indices (MARI) of the MBL producing isolates was in the range of 0.2-0.8. The multidrug resistance nature of these MBL producing isolates showed that they are a potential threat to health. Hence, measures to reduce the spread of these bacteria from the environment to human should be developed and implemented.
Title: Antibiotics susceptibility profile of Metallo-beta-lactamase producing bacterial isolates harboring blaIMP and blaNDM genes from selected sachet water samples sold in Calabar Metropolis, Nigeria
Author: Andy, I. E., Archibong, C.P.
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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