Abstract: Medicinal plants have been used for decades for the treatment of different diseases. Solanum nigrum L. is an important medicinal plant in many traditional health care system. It has been used for various diseases like liver disorder, diabeties, infections, cancer, inflammations and peptic ulcer. In the present study, we screened the whole plant of Solanum nigrum L. for their in-vivo anticancerous activity.
Result: After in-vivo screening of the extract, it was concluded that the aqeous chloroform extract of Solanum nigrum L. revealed a marked cytotoxicity against B16F10 cell lines with IC50 values 346.1 µg/ml (Romana et al.,2014). Chloroform extract showed the lowest IC50, 346.1µg/ml as compared to ethyl acetate extracts having IC50 values 355.5 µg/ml. IR and GC-MS spectral analysis confirms the presence of solanine in the extract which is an anticancerous alkaloid.
Keywords: Medicinal plant, Solanum nigrum L., extract, cytotoxicity.
Title: Anticancerous Activity of Chloroform and Ethyle Acetate Extract of Solanum nigrum L. against B16F10 Cell Lines in C57BL/6 mice
Author: Romana Rashid, Dr. Ghulam Nabi Hajam, Muzaffer Hussain Wani, Dr. Manik Sharma
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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