Abstract: Thyroid hormones enhance the basal metabolic rate. This study aimed to evaluate lipid profile in hypothyroidism in humans and experimental rats.
Materials and methods: This study included 48 subjects age range 24-48 years (24 healthy controls and 24 hypothyroid patients) and two groups of male Wister rats (normal and experimental induced hypothyroidism). Blood was collected for determination of thyroid profile (TSH, FT4 and FT3), glucose, total cholesterol, triglycerides, LDL-c and HDL-c.
Results: The levels of plasma total cholesterol, triacylglycerol and LDL-c were statistically significantly higher (p<0.001) in hypothyroidism than control in human and rats. Treatment of hypothyroid rats with thyroxin, the level of lipids reduced to be normal. Therefore, treatment of thyroid dysfunction should be taken into consideration in the cases of dyslipidemia in order to decrease the risk of coronary heart diseases.
Conclusion: Finding a laboratory model that has common characteristics with humans can be useful in pharmacological research for thyroid disorders, dyslipidemia and coronary heart diseases.
Keywords: Hypothyroid, lipid profile- rats-humans.
Title: Association of Dyslipidemia with Hypothyroidism: Comparative Study
Author: Sahar A. Al-khodair, Samar A. Damiati, Mazin A. Zamzami, Samir M. Khoja
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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