Bilateral Sequential Lung Transplant for Pulmonary Alveolar Microlithiasis

Abstract: Pulmonary alveolar microlithiasis (PAM) is a rare disease that affect bilateral lungs. It characterized by widespread deposition of calcium phosphate within the alveolar airspaces. The etiology of PAM is not well understood, some studies showed a mutation in SLC34A2 gene that encodes a sodioum-phosphate co-transport in the alveolar type 2 cells has, which result in the accumulation of microliths rich in calcioum phosphate are the cause of the disease. Other theories include exudate that forms as a result of an abnormal inflammatory response, resulting in a formation calcification. The clinical manifestation of the disease varies; many patients are asymptomatic and could progress into pulmonary fibrosis and cor pulmonale. The most effective treatment of PAM is lung transplant, medications and artificial respiratory support known to be ineffective. This case reviews the clinical manifestation, the investigations finding and the treatment with goal of contributing to a better understanding of this disease. Keywords: Bilateral Sequential Lung Transplant, Pulmonary Fibrosis and Cor Pulmonale. Title: Bilateral Sequential Lung Transplant for Pulmonary Alveolar Microlithiasis Author: Ibrahim Saud Abdullah Altamimi, Mohammed Ahmed Ali Alsahabi, Feras Khaled Abdulsalam Aledrees, Latifah Abdullah Mohammed Alnahidh, Abduljalil Hussain Mohammed Almarzooq, Badea Abdulraouf Salman Almarzooq, Hassan Ali Hassan Alyousef International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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