Abstract: In India, hemoglobinopathies are responsible for the largest number of genetic disorders and hence are of great public health hazard. Major concerned hemoglobinopathic disorders are sickle cell anemia and beta-thalassemia which are the cause of chronic ill health and financial burden to the patient. This was a hospital based study carried out at Hyderabad of Telangana state. The cases of hemoglobinopathies were identified based on clinical data, family history and red blood cell indices then hemoglobin electrophoresis was done. These disorders with genetic and biochemical components showed remarkable clinical variability ranging from mild condition to severe life threatening condition. Out of twenty eight cases, nine cases were identified as sickle cell trait, seven as sickle beta thalassemia, seven cases were suffering from beta thalassemia and three of them from sickle cell disease and two of them were identified as having hereditary persistence of fetal hemoglobin. Screening and counseling of the target population can lead to a significant reduction in affected births.
Keywords: Anaemia, Electrophoresis, Erythrocytes, Hemoglobinopathies, Sickle cell trait, beta-Thalassemia
Title: Biochemical Patterns of Hemoglobinopathies and Thalassemia Syndrome in a Tertiary Care Hospital of Telangana
Author: Archana.A.Dharwadkar, Kavita.Dharwadkar, Pragna.Rao
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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