Abstract: Diabetes mellitus is characterized by chronic hyperglycemia which is highly correlates to the initiation and progression of diabetic complications including generation of oxidative stress, neuropathy, nephropathy and cardiovascular diseases. Lycopene, the pigment principally responsible for the characteristic deep-red color of ripe tomato fruits and tomato products. The polyunsaturated fatty acids (PUFAs) may have a major role in the prevention of coronary heart disease such as n-3 that have been suggested from epidemiologic and clinical secondary avoidance trials evidences. The aim of this study is to investigate the possible protective effect of lycopene and linolenic acid against oxidative stress in rats injected with STZ. Five groups of rats were included: Normal, Diabetic untreated, diabetic treated with either lycopene or linolenic acid or combination of both . Results obtained showed that In tissues, the level of malonadialdehyde, and reduced glutathione showed highly significant increased in diabetic comparing with control. While, their level extremely significant decreased when treated with lycopene alone or combined with linolenic acid. In conclusion, Lycopene or linolenic acid or combinations of both act as free radical scavenging system that protect the damage of pancreas induce by STZ. The effect of lycopene or linolenic acid varied from tissues to another tissue that depend on bio-availabilities of each to target tissues.
Keywords: Diabetic rats- oxidative stress- rats- barin.
Title: Brain Oxidative Stress in Diabetic Rats: Role of Lycopene and Linolenic Acid
Author: Yousef A. D.AL-Khadem, Abdulrahman L. Al-Malki, Said S Moselhy
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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