Abstract: This study was conducted to investigate whether ghrelin has an anti-dipsogenic effect as seen in the neonatal chicks and eel, when administered centrally in Japanese quail Coturnix coturnix japonica). Intracerebroventricular (ICV) administration of avian ghrelin (Chicken ghrelin) reduced water intake in Japanese quail under both ad libitum and 16-h water deprived drinking conditions at doses ranging from 0.5 to 1.0 nmol/quail. This inhibitory effect was also observed when 0.5 nmol of rat ghrelin was centrally administered. On the other hand, 0.5 nmol des-acyl rat ghrelin did not reduce water intake. To elucidate the mechanism underlying the effect of ghrelin on water intake, avian B-type (or brain) natriuretic peptide (BNP), an anti-dipsogenic peptide in mammals, was centrally administered at doses ranging from 0.1 to 1.0 nmol/quail. BNP did not affect water intake in quail under both normal and water-deprived drinking conditions. These findings might suggest that ghrelin acts as an anti-dipsogenic peptide through the GHS receptor in the Japanese quail. This finding might reveals a new role for ghrelin in body fluid homeostasis.
Keywords: Japanese quail, BNP, Ghrelin, ICV administration, Water intake.
Title: Central Ghrelin Reduce Water Intake in Japanese quail
Author: S. Shousha, D. Kirat, T. Naso
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Research Publish Journals
