Challenges in Diagnostic Accuracy of Fecal Calprotectin in Pediatric Inflammatory Bowel Disease in Family Practice, Systematic Review

Abstract: This systematic review aimed to evaluates the use of Calprotectin as marker for inflammatory bowel diseases among children and the challenges facing family physicians using this method to accurate the diagnosis of IBD in children. Literature searches were conducted in Medline (through PubMed), the Cochrane Library, and Scopus. Using both MeSH terms and All Fields, the following search terms (synonyms and combinations) were used: (“Leukocyte L1 Antigen Complex” [Mesh] OR “calprotectin”[tw]) AND (“Inflammatory Bowel Diseases”[Mesh] OR “inflammatory bowel disease”[tw] OR “inflammatory bowel diseases”[tw] OR “IBD”[tw] OR “Crohn”[tw] OR “Colitis”[tw]). We searched publications up to October 2016. Thus faecal calprotectin is an accurate marker of IBD in both children and adult patients. In pediatric patients, the calprotectin assay had better sensitivity and specificity than in adult patients in identifying organic causes of chronic diarrhea. Children with organic diarrhea had significantly higher faecal calprotectin values than those without diarrhea. Keywords: Calprotectin, Inflammatory Bowel Disease, Chronic Diarrhea. Title: Challenges in Diagnostic Accuracy of Fecal Calprotectin in Pediatric Inflammatory Bowel Disease in Family Practice, Systematic Review Author: Amal Saleh Alazmi, Alhanouf Mamluh Alazmi, Noor Naif AlAzmi, Fandiyyah Rajeh alruwaili International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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