Abstract: Fabry disease is an uncommon, X-linked shortage of α-galactosidase A, affecting approximately 2 - 5 people per 1 million live births. This study as comprehensive review aiming to discuss and overview the clinical symptoms and features of Fabry disease, as well as to emphasizes the complications associated with this familial disease. The Embase, PUBMED/MEDLINE databases were searched for articles published until December 30, 2016. We included in this review every types of studies (reviews, randomized control trails, and systematic reviews) except case reports. The search strategies were through PUBMED/MEDLINE used following Mesh terms to identified relevant studies easily: (fabry disease OR fabry’s disease) AND (Complications, & clinical features. Only Human studies of reviews, meta-analysis, randomized controlled trials published in English language were included. complications of Fabry disease, such as stroke and kidney and cardiac arrest, and poor quality of life, have been revealed by numerous proof based studies, though these complications are not typical among children. The manifestations of this complex disease are multisystemic and progressive. The classic kind is seen in both males and women, although the manifestations are typically less serious in females and disease development is usually postponed compared with males.
Keywords: Fabry disease, clinical symptoms, meta-analysis, Human studies, clinical features.
Title: Clinical Features and Complications of Fabry Disease
Author: Abdulrahman Suhail Al Deiri, Alaa Khaled Safeyah, Ahmed Samir Ragab Abuhamad, Mohammad Fawzi Qusty, Fahad Saleh Alsefry, Rawad Daniel Arja, Thamer Saad shaker alghalbi, Ghalib Nasser Aldawsari, Anwar Saeed Alghamdi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Research Publish Journals
