Abstract: Fabry disease (FD) is a rare X-linked l ysosomal storage condition. The disease is defined by shortage of the lysosomal enzyme α-galactosidase A. This study aims to improve our understanding of the clinical manifestation of patients with Fabry disease and to discuss the complications that can affect patient’s life from several aspects. The following electronic databases have been searched via OvidSP: Medline Embase and The Cochrane Central Register of Controlled Trials, has been searched as well for all published studies until the December 2016.The search terms used were: Fabry disease, complications, clinical features, pain measurement, and their synonyms, Mesh terms (Medline) and headings (Embase). Fabry disease is uncommon and provides with varied symptoms in childhood and medical diagnosis is frequently delayed. Physicians needs to be familiar with early signs and symptoms of Fabry disease, which should be thought about in the differential diagnosis when a young patient presents with several non-specific or unusual but reoccurring or episodic signs, particularly inexplicable neuropathic pain, gastrointestinal signs, workout tiredness, intolerance and hypohidrosis.
Keywords: Fabry disease (FD), pain measurement, clinical features, synonyms, (Medline), hypohidrosis.
Title: Clinical Features and Complications of Fabry Disease; Systematic Review
Author: Ali Mohammed Alghamdi, Sultan said mohammed alghamdi, Faisal Sultan Alharthi, Sultan musaed aiad Albalawi, Maan khaled salem alraddadi, Nasser Faris Alahmari, Saeed Abdulrahman Alshehri
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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