Abstract: The World Health Organization (WHO) recommends the use of tenofovir as part of first line regimen for the management of Human Immunodeficiency Virus (HIV). Tenofovir can be nephrotoxic necessitating renal function assessment before its commencement. This may be a challenge in resource poor settings. Clinical Prediction Tools (CPT) for kidney dysfunction have been developed and can help to determine patients who will not require creatinine testing. For this study, data were obtained from HIV patients and analysed using three CPTs. Using a cut-off of ≥ 2 for Primary CPT and BMI CPT, 3.3% of the patients will not require creatinine testing before treatment, and for Alternate CPT, 26.4% of the patients will not require creatinine tests. The preferred CPT for our patients is the Alternate CPT because the proportion of patients who will not require creatinine testing is comparable with its prediction.
Keywords: Clinical Prediction Tool, creatinine, kidney dysfunction, HAART, HIV, Tenofovir.
Title: CLINICAL PREDICTION TOOLS FOR KIDNEY DYSFUNCTION: THEIR APPLICATION TO HIV PATIENTS IN A TERTIARY CARE CENTRE IN SOUTH EAST NIGERIA
Author: Chinyerem Cynthia Nwachukwu, Gabriel Ifeanyi Eyisi, Ifeoma Anne Njelita, Chijioke Amara Ezenyeaku, Amaechi Chinedu Nwachukwu
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Vol. 11, Issue 2, April 2023 - June 2023
Page No: 105-111
Research Publish Journals
Website: www.researchpublish.com
Published Date: 08-June-2023
