Abstract: Obsessive-compulsive disorder (OCD) with comorbid depression is relatively common, often chronic and disabling disorder with high rates of partial and/or absent response to standard, recommended treatments. This is a report for a case of treatment-resistant OCD with comorbid depression that was successfully treated with a pharmacological combination of Quetiapine plus Lamotrigine. The patient, a 49-year-old woman, had partial response to antidepressant treatment. She was prescribed lamotrigine (up to 100 mg/day) in combination with Quetiapine ( up to 100mg/day). After three weeks of this treatment, her clinical condition remarkably improved. This case suggests some preliminary evidence that the addition of glutamatergic agent Lamotrigine in combination with Quetiapine may be useful in treatment-resistant OCD with comorbid depression. However, further studies are needed to support this finding.
Keywords: OCD, depression, lamotrigine, quetiapine.
Title: Combination of Lamotrigine with Quetiapine in a Case with Treatment-Resistant Obsessive-Compulsive Disorder with Comorbid Depression
Author: Abdullah N. A. Al-Qifari
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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