Abstract: The present study was to evaluate the effectiveness of aqueous preparations of Centella asiatica in the management of haloperidol induced Parkinsonism in rats. Haloperidol is an antipsychotic medication and functions as an antagonist of dopamine. As a result, the animal is induced with Parkinsonism. It was administered to the rats as intraperitoneal injection at a dose of 1 mg/kg body weight, 4 hours and 30 minutes prior to the start of the behavioural experiment. A total of 36 Wistar albino rats were screened for this study. All the test animals weighed between 180 - 200 grams. Animals were grouped into General, Control and Test. General group were normal animals. Control group 1 consisted of haloperidol injected (intra peritoneally 1 mg/kg body weight) and Control group 2 consisted of Centella asiatica fed orally (100 mg/kg body weight). The test group 1 was treated with haloperidol + Centella asiatica and test group 2 with haloperidol + levodopa (10 mg/kg body weight). Progression of the disease was detected with rotarod, beam walking, open field and foot print analysis. L-dopa is used in the clinical treatment of Parkinson’s disease and dopamine responsive dystonia. It was fed to the rats by orogastric feeding tube at a dosage of 10 mg/kg body weight, 6 hours and 30 minutes prior to the start of motor analysis. The values were statistically analyzed for significance using Turkey post-hoc test (SPSS verson 16). Results revealed that aqueous preparation of Centella asiatica had a significant role in the management of Parkinson’s disease. There is a significant difference in between the control and the test groups. Within the test groups, test group 2 (Levodopa treated animals) performed better than the test group 1 (animals fed with Centella asiatica).
Keywords: Parkinson’s disease, Centella asiatica, Levodopa, haloperidol, dopamine.
Title: Comparative effect of Centella asiatica and levodopa on haloperidol induced Parkinsonism in Wistar albino rats
Author: Ahamed Shahal. M, Bhavya. K, Sreekumaran. E
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Research Publish Journals
