Abstract: Jatropha gossypifolia has been associated with diverse medicinal characteristics. This study was aimed at investigating the hemato-protective ability of the methanolic extract of Jatropha gossypifolia leaf (JG) and alpha-lipoic acid (ALA) on cypermethrin-induced hematotoxicity; and to investigate the possible hematotoxic effect of the plant extract on the rats. The animals were grouped into eight groups of seven rats each and were administered as follows: Group I (control), corn oil; Group II, cypermethrin (CYP) (20mg/kg); Group III, CYP + (JG50mg/kg); Group IV, CYP + JG100mg/kg; Group V, CYP + ALA50mg/kg; Group VI, JG50mg/kg; Group VII, JG100mg/kg; and Group VIII, ALA50mg/kg. Data from this study showed that cypermethrin significantly (P<0.05) increased the amount of the red blood cells (RBC), white blood cells (WBC), lymphocytes (LYMP) and significantly (P<0.05) decreased the concentrations of the mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and mean corpuscular volume (MCV) when compared to control. It also caused a non-significant (P>0.05) increase in hematocrit (HCT), haemoglobin (HG), granulocytes (GRAN) and platelets when compared to the control. Co-administration with the different doses of the methanolic extract of Jatropha gossypifolia and ALA were able to reverse these alterations. Thus, we concluded that the methanolic extract of Jatropha gossypifolia at the doses considered are safe and will elicit hemato-protective effect on cypermethrin-induced hematotoxicity.
Keywords: Jatropha gossypifolia, alpha-lipoic acid, cypermethrin, hematotoxicity, methanolic extract.
Title: Comparative Effects of Jatropha gossypifolia Leaf and Alpha-Lipoic Acid on The Hematological Profile of Rats Exposed to Cypermethrin
Author: Opeyemi Faokunla, Oluseyi Akinloye, Regina Ugbaja, Abideen Adeogun
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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