Abstract: There have been many recent reports of biological activity of derivatives of acyclic aldazines and ketazines against microorganisms. Current work has been carried out to elucidate the importance of the azine framework (>C=N-N=C<) in exhibition of biological activity and to hence establish the pharmacophore in the lead compound. The scope of this paper is to compare the activity of 1,4-diazabutadiene or 1,4-DAD (-N=CH-CH=N-) which is a structural isomer of azine and is only different in the arrangement of atoms. The biological activities of two isomeric compounds 4-hydroxybenzalazine and N,N’-bis(4-hydroxyphenyl)-1,4-diazabutadiene were tested against two bacterial species - E.coli, S.aureus. The azine was found to be significantly more active against both the Gram positive bacteria S.aureus as well as the Gram negative E.coli indicating not only its enhanced potency as against its structural isomer but also its broad spectrum mode of action.
Keywords: Azine, antibacterial, E.coli, S.aureus, broad spectrum.
Title: Comparative study of antimicrobial activities of azines and 1,4-diazabutadienes to establish the pharmacophore in the lead
Author: Gokul Ganesan, Niloufer K. Kotwal, Sreela Dasgupta
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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