Abstract: Comparison of the use of Cyclosporine and Tacrolimus as primary immunosuppression in renal transplantation at 5years of follow-up by evaluating –
• Graft Survival and Patient Survival rate at 6 months, 1 year, 3 years and 5 years between Cyclosporine and Tacrolimus groups.
• Survival analysis of patients in Cyclosporine or Tacrolimus groups using Kaplan Meier Survival Curve.
• Assessment of Drug induced toxicity in between Cyclosporine and Tacrolimus groups
Materials & Methods: There were 99 renal transplantations done between 1990-2010.
• Of these, 97 were Live related kidney transplant and 2 were Cadaver transplant.
• 52/99 patients fulfilled the inclusion criteria and were included in the study.
• Mean Duration of Follow-up was 62.7 months.
Results: Hypertension was more common in CSA group (89% vs 62.5%, p=0.38)
• Dyslipidemia was more common in CSA group (55.56% vs 6.25%, p=0.002, Significant )
• DGF was more in the TAC group (25% vs 11.11%, p= 0.2005)
• Hyperkalemia was more in TAC group (6.25% vs 3%, p=0.857)
• NODAT was more common in TAC group (56.25% vs 27.78%, p=0.0348)
• At 5 years, the survival rate of graft and patient in the Cyclosporine group was (75% & 80.56% ) versus the Tacrolimus group was (87.5% & 87.5%) respectively.
• Projected Graft half life in TAC group was 27 yrs versus CSA group of 10.1 years.
Conclusions: Tacrolimus was more effacious than cyclosporine in terms of allograft survival rate at 5 years of follow up. Also Tacrolimus had fewer side effects as compared to cyclosporine.
Keywords: Tacrolinmus and Cyclosporine, TAC group.
Title: Comparative Study of Efficacy of Cyclosporine and Tacrolimus in Renal Transplantation
Author: Geeta S Sheth, Kalpana S Mehta
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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