Abstract: Medicinal plants are known to contain different bioactive components with enormous therapeutic potential to cure many diseases in human beings. In this research study two different medicinal plants that are used for the treatment of various illnesses in South West Nigeria, were subjected to toxicity test using brine shrimp lethality test at different concentrations. The percentage mortality increases as the extract concentration increases and none of the extracts exhibited higher percentage mortality than the standard drugs used. The hexane extract of Annona muricata exhibited higher percentage mortality at higher concentrations than the hexane extract of Maytenus senegalensis. The ethyl acetate extracts of the two plants had the same percentage mortality at 60.00 µg/ml, 80.00 µg/ml and 100.00 µg/ml concentrations. The Annona muricata methanol extract showed better toxicity than Maytenus senegalensis methanol extract at all concentrations. It exhibits the most significant cytotoxicity activity against brine shrimp (Artemia salina) having the lowest lethal concentration (LC50) value of 32.515 µg/ml. The two medicinal plants have demonstrated good cytotoxicity activity and it is an indication that they can exhibit good anticancer property when tested against some cancer cell lines.
Keywords: Medicinal plants, Percentage mortality, Toxicity, Anticancer property, Lethal, concentration.
Title: Comparative Study on the Brine Shrimp Lethality Assay of Hexane, Ethyl Acetate & Methanol Extracts of Maytenus senegalensis Stem Part & Annona muricata Aerial Part
Author: O. B. Tojola, L. Lajide, B. J. Owolabi, M. T. Olaleye
International Journal of Mathematics and Physical Sciences Research
ISSN 2348-5736 (Online)
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