Abstract: The aim of this review study was to discuss the treatment approaches of Pemphigus vulgaris (PV), and also to review the dermatological lesions which are mostly oral mucosal and face area lesions. We conducted a computerized search through; PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases, for relevant articles reporting data on lesions and treatment of pemphigus vulgaris up to December, 2016. And reference lists were searched for more relevant articles concerned with treatment modality for pemphigus vulgaris. Restriction were applied in the search method to English language and only human subjects. Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that at first materializes through intraoral lesions, which infected various other mucous membranes and the skin. The etiology of pemphigus vulgaris is still unknown, although the disease has brought in substantial rate of interest. The pemphigus group of disease is characterized by the production of autoantibodies versus intercellular materials and is thus identified as autoimmune diseases. In pemphigus vulgaris, treatment with systemic glucocorticosteroids is lifesaving; it could, nevertheless, create severe side effects, consisting of death. A patient with pemphigus vulgaris as well as myasthenia gravis was treated for roughly 5 years with the cholinomimetic Mestinon (pyridostigmine bromide), Imuran (azathioprine), and a topical corticosteroid gel before they have to present systemic glucocorticosteroids.
Keywords: Pemphigus vulgaris (PV), Cochrane Central Register of Controlled Trials.
Title: Dermatological Lesions of Pemphigus Vulgaris, And Treatment Approaches
Author: Yasser Yahya Ali Al-Habtar Asiri, Abdullah Khallufah Abdullah Asiri, Ibrahim Hassan A. Abu Saq, Naif Dahman Abdullah Alshehri, Salem Mohammed Alqarni, Yasser Dhafer Ali Alshahrani, Abdulwahab Salem Ahmad Alghamdi, Abdullah Ali Abdullah Alqahtani, Hassan Fayez Abdullah Alshehri, Saleh Abdullah M Alqahtani, Yazeed Mohammed Yahya Al Hadi, Fahad Abdulrahman Alazragi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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