Abstract: Diabetic nephropathy (DN) or diabetic kidney disease means the degeneration of kidney function which can be seen in chronic type 1 and type 2 diabetes mellitus patients. Diabetic nephropathy is the leading cause of chronic renal disease and a major cause of cardiovascular mortality. The development of the disease is known to occur in different type stages and is connected to glycemic and blood pressure control. Although, despite aggressive blood sugar control the prevalence of chronic kidney disease (CKD) I in diabetic people have not been seen in the last two decades: which has now lead to the recognition of new additional factors in the development. The two main risk factors for diabetic nephropathy are hyperglycemia and arterial hypertension, but the genetic susceptibility in both type 1 and type 2 diabetes is of great importance. Other risk factors are smoking, dyslipidemia, proteinuria, glomerular hyperfiltration, and dietary factors. The nutritional station of the patient is a very vital and changeable factor that may influence CKD procedure and the result. It directly comes from the traditional diet choices that the patient makes base on poor nutritional recognition. Dietary management of DN victims is challenging, as the factors of diet overload on the kidney function required to be maintained with malnutrition. The single best evidence-based therapy for diabetic nephropathy is therapy with a RAS-blocking medication. The introduction of antioxidant and anti-inflammatory agents to this field had also added a wealth of knowledge. However, many of these agents are still waiting for well-designed clinical studies to prove their beneficial therapeutic role.
Keywords: Diabetic Nephropathy(DN), renal disease, Nano formulation, Diabetes mellitus(DM)
Title: Diabetic nephropathy and its therapeutic options: A Review
Author: Faruk Yusuf, Yousif Safaa Aldeen Subhi Al Daghestani, Manish Kumar, Indu Melkani, Dileep Singh Baghel, Bimlesh Kumar, Linu Dash, Anupriya, Varimadugu Bhanukirankumar Reddy, Amrik Singh, Amarish Kumar Sharma
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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