Abstract: This study intended to evaluate diethanolamine-induced toxicity and its possible mitigation by potent antioxidant curcumin. Diethanolamine is an organic compound and highly reactive with two functional groups, alcohol and amine. It is used in many personal care products as well as in pharmaceutical industries. Lipid peroxidation was measured by the change in optical density of the prepared solutions. Homogenates prepared from liver of healthy mice were treated with varying concentrations of DEA (25 to 200 µg/ml) with and without curcumin (0.5 to 2.5 µg/ml). Significant (p<0.05) increase in lipid peroxidation and remarkable decrease in protein content was noted in DEA-treated homogenates as compared to control. However, addition of diethanolamine (200 µg/ml) along with curcumin (0.5 to 2.5 µg/ml) caused significant (p<0.05) decrease in lipid peroxidation as well as increase in protein content. These findings suggest that curcumin significantly ameliorate diethanolamine-induced lipid peroxidation and protein content which is due to its antioxidant property.
Keywords: diethanolamine, oxidative stress, mitigation, curcumin.
Title: DIETHANOLAMINE-INDUCED OXIDATIVE STRESS AND ITS MITIGATION BY CURCUMIN: AN IN VITRO STUDY
Author: Hetal Doctor, Sanman Samova, R.J Verma
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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