Abstract: The heavy metal pollutants well known to be highly toxic to both human and animals, are widely distributed due to its use in various industries. One of them and caused highly effects is Lead which naturally occurring elements. The salts of them are soluble and forming aqueous solutions, cannot be separated by usually physical means of separation. Lead intervenes with a diversity of most of body processes and is toxic to many tissues, exposure for long time to a sub lethal dose associated with oxidative stress, damage of DNA and revealed to be a risk factor for kidney, liver. Cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. The exposure lead to renal dysfunction, hepatic damage, anemia, and hypertension. Cadmium may made oxidative damage in different tissues. In this study were carried out on investigate the most toxic effects of lead, cadmium, and zinc with trial to estimate this toxicity, on the biochemical blood parameters and function of liver and kidney on heavy metals-unprotected animals. Oral administration of their salts, we found Lead and Cadmium had significantly decreased RBC count, WBC, hemoglobin level, hematocrit value, MCHC, Total protein, albumin, and A/G ratio. In contrast, MCV, MCH, urea, creatinine, MDA, SOD, AST, and ALT were significantly increased. At kidneys and liver, the observed alterations could be a compensatory reaction to unlike heavy metals accretion in the organs. Moreover, the probable individual mechanisms in ROS eradication. In conclusion lead induces oxidative stress in various tissues.
Keywords: Heavy metals, Lead, Cadmium, Zinc, Rats, Biochemical, Kidney, liver.
Title: DISTURBED HOMEOSTASIS OF CERTAIN HEAVY METALS ON EXPOSED MALE ALBINO RATS
Author: Nabil A. Soliman, Ibrahim M. Elshorbagy, Mohamed B. El-Nile, Shimaa S. El-Malah, Ahmed K. El-Sayed, Mona M. Elsherbiny
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Research Publish Journals
