Abstract: The effect of Hibiscus sabdariffa calyces extract on cadmium (Cd) induced biochemical changes in the brain of Clarias garipenus was studied. Forty (40) juveniles African catfish (Clarias gariepinus) were used for the study. Test group was administered 0.3 mg/l Cd for two weeks. The activities of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) formation were determined, phytochemical screening of plant extract and histopathology examination of brain tissue was also carried out. Phytochemical screening of Hibiscus sabdariffa calyces revealed the presence of Alkaloids, Carbohydrate, Amino acids, Saponin, Proteins, Glycoside, Flavonoids, Tanins and Phenol while Anthraquiones, Steroids and Sterols were absent. There was no significant difference in MDA levels and SOD activity of all test groups when compared to the control, but a slight decrease (p˂0.05) was seen in the CAT activity. Histopathological observation on the brain showed that there was discolouration on the brain of fish exposed to Cd, mild degenerative changes were also observed. The Environment is constantly invaded with pollutants, increasing the risk of cellular damage from reactive oxygen species (ROS), Hibiscus sabdariffa calyces extract is rich in antioxidants thus it can protect cells/tissues from free radical damage and oxidative stress.
Keywords: Hibiscus sabdariffa, Clarias garipenus, Superoxide dismutase, Catalase, Malondialdehyde.
Title: Effect of Aqueous Extract of Hibiscus Sabdarifa on Cadmium Induced Biochemical Changes in Brain of Clarias Gariepinus
Author: Sarah. A. Akande, Otunuya. O. Obi
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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