Abstract: To assess the effect of female body mass index (BMI) on IVF outcomes in Saudi women undergoing IVF with or without intracytoplasmic sperm injection (ICSI).
Design: Retrospective cohort analysis.
Setting: University-affiliated IVF Unit.
Patient(s): Patients undergoing fresh IVF cycle with or without ICSI treatment, 2011-2013.
Intervention(s): subjects divided into 4 subgroups according to their BMI: normoweight with BMI 18.5- 24.9 kg/m2 (n = 93) overweight with BMI 25.0 - 29.9 kg/m2 (n = 99), moderately obese (class I) with BMI 30.0 - 34.9 kg/m2 (n = 93) and severely obese (class II/III) with BMI ≥ 35.0 kg/m2 (n = 73).
Main outcome Measure(s): The primary outcome was biochemical pregnancy which was defined as the detection of a positive β- hCG concentration 2 weeks after embryo transfer. Ovarian stimulation parameters and IVF/ICSI cycle outcomes were compared. Other factors associated with BMI were demographic, clinical, and IVF lab data. Association between BMI and biochemical pregnancy was done by multivariate analyses to control for confounding.
Result(s): In our study, BMI was not found to be significantly associated with biochemical pregnancy. Compared to the normal BMI subgroup, the adjusted OR (95% CI) for the overweight, moderately obese and severely obese subgroups were 0.93 (0.43 – 2.00), 0.83 (0.38 – 1.84), and 1.67 (0.76 – 3.69), respectively.
Conclusion(s): Female BMI does not appear to have an adverse effect on biochemical pregnancy rates in women undergoing IVF/ICSI treatment. However, counseling women on the increased obstetric and neonatal complications associated with increased maternal BMI prior to undergoing this treatment is mandatory
Keywords: Obesity, body mass index, in vitro fertilization, biochemical pregnancy, infertility.
Title: Effect of Female Body Mass Index on the Outcome of IVF / ICSI Treatment Cycles in Saudi Women
Author: Saleh AlAssiri, Hadeel AlMadany, Khawlah Ateeq, Hani Tamim
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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