Abstract: The main purpose of writing this review is to evaluate the efficacy and safety of lamotrigine monotherapy for treating absence seizure in paediatric population. Absence epilepsy is one of the most common childhood epilepsy syndrome account for 2-10% of seizures in children. Effective control of absence seizures is important as it increases the risk of accidental injury (head injuries and bicycle injuries) in children. (Holmes et al, 2008 and Cerminara et al, 2012)
According to treatment guideline, ethosuximide or valproic acid is generally recommended for the first line treatment of absence seizures, however this study will assess the effectiveness of LTG as initial treatment in comparison to other conventional AEDs. This is done by analysing an open-label trial conducted with Japanese and South Korean paediatric patients and compare its result with another double-blind clinical study. The results gathered during research will be displayed graphically to show visual comparison and in tabulated form to indicate the correlation. In conclusion, the findings of the present review articles suggest that LTG monotherapy has managed to offer freedom from seizures to 35% patients suffering from absence epilepsy without generating any severe adverse effects. Hence LTG can be considered as a first-line therapy for treating absence seizure. However, this was a small-scale, uncontrolled and open label investigation hence, more research need to be done on a large scale before confirming it as an effective first-line drug. (Yasomoto et al, 2016)
Keywords: AED Anti-epileptic drug; CAE Childhood absence epilepsy; EEG Electroencephalogram; VPA Sodium valproate; LTG Lamotrigine.
Title: Efficacy and Safety of Lamotrigine Monotherapy: A Review Study
Author: Warsi Sareen
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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