Efficacy of Kybella Injection in the Treatment of Sub-Mental Fat: A Systematic Review

Sally Alkhonizi, Rahaf Albenayan, Rimah Alkhonizi

Abstract: weather Kybella injection VS other technique in double chin patients is more effective in getting rid of sub-mental fullness.

Objectives: To conduct a systematic review of the efficacy and adverse events (AEs) of Kybella injection in sub-mental fat reduction.

Background: Deoxycholic acid, also known as Kybella is a new injectable treatment that melts away the excess fat that causes double chins. The most common side effects of Kybella include swelling, bruising, pain, numbness, redness, and areas of hardness in the treatment area. Weather Kybella is really effective in treating submental fullness is true or not that’s the goal of this paper.

Design: Systematic Review

Methods: We conducted literature searches in PubMed, Cochrane, and EMBASE searching for descriptive and comparative studies evaluating the efficacy and safety of Kybella injections, which met predefined inclusion criteria.

Study selection: studies with information Kybella VS no Kybella procedures. Only randomized clinical trials and comparative studies were included.

Data extraction: data of trial design, weight (pre and post treatment), dose of Kybella, frequency of Kybella injection, duration of treatment, assessment method for double chin, sample size, total number of female and male, studies limitation and side effects.

Main Outcomes and Measures: sub-mental fullness improvement according to measurement scale or self-assessment scale, patient satisfaction and adverse events (AEs).

Results: Overall there was improvement in the grade of sub-mental reduction and patient satisfaction in all the studies. The primary efficacy endpoint, a reduction in sub-mental fat was assessed using ≥ 1 grade improvement on Clinician- Reported SMF Rating Scales [CR-SMFRS] for 2 mg/cm2 .

Conclusions: In this systematic review, the effect of Kybella in the treatment of sub-mental fat was reviewed. Overall there was improvement in the grade of sub-mental reduction and patient satisfaction.

Keywords: Cosmetic Techniques, Cosmetic treatment, Kybella, and Deoxycholic Acid.

Title: Efficacy of Kybella Injection in the Treatment of Sub-Mental Fat: A Systematic Review

Author: Sally Alkhonizi, Rahaf Albenayan, Rimah Alkhonizi

International Journal of Healthcare Sciences   

ISSN 2348-5728 (Online)

Research Publish Journals

Vol. 5, Issue 1, April 2017 – September 2017

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Efficacy of Kybella Injection in the Treatment of Sub-Mental Fat: A Systematic Review by Sally Alkhonizi, Rahaf Albenayan, Rimah Alkhonizi