Epidemiological and Etiology Review of Melanoma Worldwide: Systematic Review

Abstract: Surgical treatment is the only alleviative treatment for main cutaneous cancer malignancy, for that reason it is necessary to determine excision margins that reduce risk of regional reoccurrence, far-off reoccurrence and death.6 RCTs with 4233 patients were included. Narrow margins were defined as 1 or 2 cm of medically regular skin around the melanoma; large margins as 3, 4 or 5 cm. Risk ratios (HR) were as follows (HR > 1 shows broad margin better): overall survival 1.09 (95% CI 0.98-- 1.22; p = 0.1); melanoma-specific survival 1.17 (CI 1.03-- 1.34; p = 0.02); recurrence-free survival 1.08 (CI 0.97-- 1.20; p = 0.2); loco-regional reoccurrence 1.10 (CI 0.96-- 1.26; p = 0.2), with no evidence of heterogeneity in between trials for any endpoint or within subgroup analyses. There was an 94% probability that overall survival was even worse with a narrow margin and a 43% likelihood that it was more than 10% even worse in proportional terms (i.e. HR > 1.1). Possibilities that narrow margins were even worse were 99%, 92% and 92% for melanoma-specific survival, recurrence-free survival and loco-regional re-occurrence respectively.The main aim of this systematic review is to provide an updated review of cutaneous melanoma surgical margins We have used standard meta-analysis methods, and for the first time, a probability-based analysis of the data. Keywords: Surgical treatment, melanoma, systematic review, methods. Title: Epidemiological and Etiology Review of Melanoma Worldwide: Systematic Review Author: Wafaa Abdullkareem M Abdullghaffar, Mishael Tariq Saleh Alghamdi, Fawaz Numan Abdulaziz Almulhim, Mohammed Saeed M Alghamdi, Hussein Ali M Fitaihi, Raed Tlaat Abdullah Miralam, Hussain Khalid H Kaaki, Mohammed Rabah A Alkhateeb International Journal of Healthcare Sciences ISSN 2348-5728 (Online) Research Publish Journals

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