Abstract: Skeletal muscle is the significant site for disposal of consumed glucose in lean healthy normal glucose tolerance (NGT) individuals. Following a meal, approximately one third of ingested glucose is used up by the liver and the rest by peripheral tissues, mainly skeletal muscle by means of an insulin dependent system. This review was aim to overview and discuss the role of skeletal muscle fat accumulation, lipotoxicity and in fact muscle insulin resistance and especially the most central role in the pathophysiological events leading to T2DM. We performed an electronic search through medical databases; PubMed/Midline, Embase for all these relevant studies that were published up to December 2016, in English language and containing only human subject. we then searched the references found in identified articles for relevant studies concerning, skeletal muscle lipotoxicity and insulin resistance. Insulin resistance in skeletal muscle appears by decreased insulin-stimulated glucose uptake and results from impaired insulin signaling and multiple post-receptor intracellular flaws consisting of impaired glucose transportation, glucose phosphorylation, and decreased glucose oxidation and glycogen synthesis. Insulin resistance is a core problem in type 2 diabetes, it is also related to obesity and the metabolic syndrome.
Keywords: T2DM, lipotoxicity, PubMed/Midline, Embase, Etiology of Skeletal Muscle.
Title: Etiology of Skeletal Muscle Lipotoxicity and Insulin Resistance and Type 2 Diabetes
Author: Essa Ali A Hamadi, Nawaf Mohammed Abdu Akour, Mansour Hajed Musheh Al-Harthi, Ayed Abdullah Al jahrash, Abdulaziz Hussain Al makfor, Khalid Abdulaziz Dealan
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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