Abstract: Newborn infants with seizures are at risk for neonatal death and survivors at risk for neurologic impairment, developmental delay, and later epilepsy. Despite increasingly sophisticated neonatal intensive care, clinicians managing seizures remain challenged by difficult prognostic and therapeutic questions. Our objective was to determine the etiology of neonatal seizure and the proper treatment in which could be most effective for treating neonatal seizures, in order to guide development of an evidence-based treatment algorithm. We searched MEDLINE via PubMed from inception to Octorber 2016. A librarian trained in literature search strategies assisted us in the design of our search terms, which were subsequently reviewed by a second librarian. The search was limited to humans and English language articles and included the specific search terms: National Library of Medicine Medical Subject Heading [MeSH] term "Seizures/therapy" AND ("Infant, Newborn"[Mesh] OR neonat*) AND (Humans [Mesh] AND English [lang]). Phenobarbital is the preferred first drug of choice for acute treatment of neonatal seizures, both among neonatologists and paediatric neurologists. When this treatment fails, neonatologists seem to initially favour higher doses of phenobarbital while paediatric neurologists generally prefer to use other anti-epileptic medications and also more frequently off-label drugs such as levetiracetam and topiramate.
Keywords: Newborn infants, Etiology, Onset and treatment strategy.
Title: Etiology, Onset and Treatment Strategy of Neonatal Seizures, Systemic Review
Author: Jawaher Musnad Alanazi, Jawaher Musnad S Alanazi, Fatimah Hamad S Alfeheid, Amal Dhabyan Z Aldhilan, Entsar Owaid M Alanazi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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