Abstract: Paracetamol; a drug widely used in management of pain and fever. This research aims to evaluate the Efficacy of paracetamol in the reduction of edema. Croton oil and acetone solution was used to induce the edema. The rats were administered with paracetamol for 21 days after which the croton oil and acetone solution was applied to the inner surface of right ear and same amount of acetone was applied to the left ear while the control group received normal saline also for 21 days. The edema was measured by the difference between the weights of the cut ear tissue which was confirmed by histological analysis. The result showed that there was about 88.46% edema inhibition as compared to the control. Furthermore, the histological findings revealed a significant decrease in edema and inflammation as well as less tissue congestion in the paracetamol group as compared to the control. From this study, paracetomol has shown a promising result in reducing edema and also exhibited some level of ant-inflammatory properties. Thus, this can be helpful in suppressing mild to moderate sub cutaneous tissue edema as well eliciting some ant-inflammatory effect.
Keywords: Paracetamol, edema, inflammation, neutrophils, tissues.
Title: Evaluating the potential Anti-edema effect of Paracetamol on Sprague-Dawley rats
Author: Umar Ibrahim Maryam, Nordin Simbak, Ibrahim Haruna Sani, Atif Amin Baig, Umar Faruk Abdullahi , Rufa’i Umar Zubair, Aliya I.S, Thant Zin, Swethadri GKM , Hadiza Abdullahi Abubakar
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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