Abstract: The present study was to assess the antimicrobial activity of isolated bioactive compound from the ethanolic leaves extract of Erythrina indica. Bioactive fraction was identified as 13Docosenamide,(Z). Dosage dependent antibacterial activity of 13Docosenamide,(Z) was assessed against clinical isolates such as gram positive bacteria (Bacillus subtilis, Streptococcus pneumonia and Staphylococcus aureus) and gram negative bacteria (Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Salmonella typhi, Salmonella paratyphi, Vibrio parahemolyticus and Vibrio cholera). It was observed that, 13Docosenamide,(Z) was able to inhibit Salmonella typhi and Salmonella paratyphi completely at 400µg/ml concentration. Above 79% inhibition was seen in Vibrio parahemolyticus and Vibrio cholera and less than 50% inhibition was observed in Escherichia coli and Bacillus subtilis with the maximum tested concentration of 400µg/ml. Among the tested microorganisms Klebsiella pneumonia, Proteus mirabilis, Streptococcus pneumonia and Staphylococcus aureus were not inhibited by the 13Docosenamide,(Z). This study confirmed the antibacterial effect of isolated compound against selected microorganisms establishing the medicinal activity of Erythrina indica.
Keywords: Erythrina indica, ethanol extract, 13Docosenamide,(Z), Salmonella typhi, Salmonella paratyphi, Vibrio parahemolyticus and Vibrio cholera.
Title: Evaluation of antibacterial activity of bioactive compound from ethanolic leaves extract of Erythrina indica
Author: R.Priya, S.Maneemegalai
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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