Abstract: The precancerous nature of OSMF and Leukoplakia have been very well established, malignant transformation rates have been reported in both these cases. Tobacco consummation is the most important oral cavity cancer risk factors. Burst of (ROS) have been implicated in the development of oral carcinoma in tobacco and betel quid chewers (1). Epidemiological studies support the protective role of diet rich in antioxidants which could alleviate oxidative stress to some extent. In view of this a preliminary evaluation of chemoprevention with antioxidant supplementation was designed to study the protective effect with clinical response.
Twenty five patients each of OSMF and Leukoplakia were evaluated to study the beneficial role of antioxidant supplementation. Blood samples were collected from patients (Leukoplakia & OSMF) , enrolled in Oral Radiology department of Nair college & Hospital. The patients were clinically examined by measuring mouth opening and tongue protrusion in case of OSMF patients and the size of lesion was measured in case of Leukoplakia patients pre and post antioxidant therapy. Blood samples were collected and level of antioxidant enzyme GSH-Px, non-enzymatic antioxidant β-caroteen and α-tocopherol were determined, plasma levels of TBARS expressed as MDA was determined to find the extent of lipid per oxidation and plasma level of whole blood was used for estimation of Hb.
Enzyme activity was represented as mean± SD and the data was analyzed statistically. Student –t test was applied to study the comparison of pretreatment and post treatment therapy. Clinical improvements seen in both the precancerous groups were significant though biochemical parameters such as GSHP-X enzyme and non-enzymatic antioxidant such as β- carotene and α-tocopherol and MDA showed marginal improvement.
Long term supplementation of antioxidant vitamins to the patients is necessary to validate the use of such therapy in precancerous condition and prevent malignant conversion.
Keywords: OSMF – Oral Sub mucous fibrosis, ACD- Acid Citrate, ROS-Reactive Oxygen Species.
Title: Evaluation of Antioxidant Supplementation in the Management of Oral Sub mucous Fibrosis and Leukoplakia Patients
Author: Dr. Sarita Basu, Dr. V. Naga Guhan
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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