Abstract: The thiohydantoin nucleus is a 5-membered ring system containing a reactive cyclic thiourea core. This heterocycle is used for the synthesis of drugs with antidiabetic, antimicrobial, anticancer, anticonvulsant, antiinflammatory, antiulcer and antiarrhythmic agents. The aim of the study was to evaluate the antioxidant and cytotoxic activity of the synthetic compound, 2-thiohydantoin. The present study gives information regarding four different in vitro methods that were used to measure the antioxidant activity of the synthetic compound, 2-thiohydantoin. In vitro studies on the effect of 2-thiohydantoin on scavenging 2,2-diphenyl-1-picrylhydrazl radical(DPPH•), 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) radical cation (ABTS•), hydroxyl radical (OH•) and superoxide anion radical (O2•-) confirmed the free radical scavenging and antioxidant activity of 2-thiohydantoin. The cytotoxic activity of 2-thiohydantoin on L6 & 3T3-L cells was determined using MTT assay. The IC50 values of 2-thiohydantoin on L6 and 3T3-L cells was 21.25 µg and 25.25 µg respectively. These results indicate that the synthetic compound, 2-thiohydantoin has good antioxidant and significant cytotoxic activity.
Keywords: thiohydantoin, antioxidant, cytotoxic, free radical, DPPH.
Title: Evaluation of in vitro antioxidant and cytotoxic activity study of 2-thiohydantoin
Author: Uma.S, Dr.P.T.Devika
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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