Abstract: This is a retrospective observational case control study aimed to evaluate mucins histo-chemical pattern in breast, colonic, ovarian, and lung adenocarcinomas. The study was conducted in Khartoum state hospitals, from December 2013, to April 2015. Sixty two formalin fixed paraffin embedded tissue blocks from patients with adenocarcinoma used as case samples and twenty formalin fixed paraffin embedded tissue blocks from corresponding normal tissues were used as controls samples. Tissue sections were stained by Mayer's Haematoxylin and PAS-diastase, Phenylhydrazine-PAS, Alcian blue, combined alcian blue-PAS, and combined aldehyde fuchsin-alcian blue techniques. Age group of 61+ were the most observed ages constituted 29(46.8%), of which females were the major subject which constituted 37(59.7%). Breast adenocarcinoma was the most observed which constituted 23(37.1%). Carboxylated Acid mucin was the predominant type with 29(46.8%), followed by neutral, and sulfated acid mucins which constituted 17(27.4%), and 16(25.8%) respectively. The most observed mucin in colonic and breast adenocarcinomas was carboxylated acid mucin which constitute 8(12.9%) , 7(11.2%) respectively, followed by neutral mucin among breast adenocarcinoma, then sulfated acid mucin among lung adenocarcinoma which constitute 5(8%), and 4(6.4%) respectively. Its concluded that mucin histochemical patterns have valuable, cost-effective, and important role in the diagnosis of adenocarcinomas. Acid mucin found to be the most predominant mucin in breast, colonic, ovarian, and lung adenocarcinomas. Its recommended to consider mucin histochemistry in diagnosis of adenocarcinomas. Mucin genes immune-expression techniques will be valuable diagnostic tool to discriminate primary from metastatic tumours. And it can elucidate the patho-physiological significance of mucin in adenocarcinomas.
Keywords: Mucin, Neutral Mucin, Acid Mucin, Adenocarcinoma, Sialomucin.
Title: Evaluation of Mucin Histo-Chemical Pattern in Breast, Colonic, Ovarian and Lung Adenocarcinomas
Author: MUAZ OSMAN FAGARE
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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