Abstract: Polycystic ovarian syndrome (PCOS) has been one of a major public health problem in Sudan that leads to medical consequences. It causes multifactorial in etiology such as menstrual dysfunction, hyperandrogenism, hirsutism, insulin resistance (IR), dyslipidemia and obesity which increased risk of diabetes mellitus and cardiovascular disease.
Objective: The present study was designed to assess serum prolactin and insulin resistance in PCOS Sudanese women and to compare them with healthy women as controls.
Materials and Methods: This study, was a descriptive, analytic, cross- sectional and hospital-based study, carried in Khartoum- State- Sudan; it was carried out in March 2013 to May 2014. 200 women with PCOS were enrolled in this study, they compared with 100 healthy women as control group, all of them were age-and weight-matched, Samples were taken after overnight fasting, then serum insulin and prolactin levels were analyzed using ELISA technique and enzymatic colorimetric method. Data management and analysis was done by using Microsoft excel and SPSS software, version 20.00.
Results: The patients with PCOS, having a mean age of 29.61± 5.4 years and mean age 31.23±4.93 years of control group, were included in the study, in PCOS group the (mean ± SD) of serum insulin, prolactin and blood glucose were11.06±6.21 µIU/ml,397.95±25.17 ng/ml, 95.75±22.53 mg/dl, respectively while that of control group, the (mean ± SD) of serum insulin, prolactin and blood glucose were 4.52±1.60 µIU/ml, 249.15±25.76 ng/ml and 80.35±11.76 mg/dl respectively. There was statistically significant increased levels insulin, prolactin and blood glucose in PCOS group when compared to the control group (P<0.05).
Conclusion: It concluded that there was significantly higher fasting insulin, glucose and HOMA in PCOS
Patients, indicates presence of insulin resistance. IR may have a potential role in the prediction of dysglycemic disease in women with PCOS. Our study, observed that there was no any correlation between serum prolactin, serum insulin and BMI in the study group.
Keywords: PCOS, Insulin resistance and serum prolactin, Sudanese.
Title: Evaluation of Serum Prolactin and Insulin Resistance in Sudanese Women with Polycystic Ovarian Syndrome
Author: Omer Mohamed Shoaib
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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