Abstract: Latent autoimmune diabetes in adults (LADA) is a progressive autoimmune disease that result slowly in insulin deficiency and the need of insulin injection. The prevalence of this non-classical form of diabetes is growing higher and the evaluation of the main criteria of diagnose and the importance of metabolic syndrome is essential. As a result, we took a sample of the Albanian population with type 2 diabetes and LADA in order to compare the parameters of the metabolic syndrome and insulin resistance in both groups and to evaluate the potential correlation.
Materials and Methods: The study design was cross-sectional and it involved 149 participants, 50 females and 99 males. All participants met the criteria above: 1) new diagnose of diabetes in patient over 30 years old, 2) onset of disease in less than a year 3) no use of insulin since the diagnose. Anthropometric data, level od C-peptide and fasting insulin were measured in all participants. All data were analysed with SPSS 10.0 and ANOVA One-Way.
Results: The mean age of the participants in the study was 43,22 ± 7,1 years old. Patients with LADA had BMI of 25,07 3,82, lower than in type 2 Diabetes. Fasting insulin concentration was lower in LADA than in type 2 diabetes in our study (26,8 ± 0,4 versus 31,5 ±19,3) confirming the insulin deficiency in LADA in comparison with type 2 diabetes where the main event is insulin resistance rather than insulinopenia. The same goes to the level of C-peptide where in the LADA group is lower than in type 2 Diabetes.
The presence of GAD antibodies was significantly higher in LADA (6.83 5,6) than in type 2 Diabetes (0.57 0,09).
Conclusions: Our observations indicate that metabolic syndrome and insulin resistance are present in LADA but not higher than in type 2 diabetes. Higher BMI was present in type 2 Diabetes but was not significant in diagnose of LADA. Insulin and C-peptide level were lower in LADA and anti-GAD was statistically important in LADA rather than type 2 Diabetes confirming its role in differential diagnose.
Keywords: Latent autoimmune diabetes in adults (LADA), insulin resistance metabolic syndrome.
Title: EVALUATION OF THE PARAMETERS OF INSULIN RESISTANCE AND METABOLIC SYNDROME IN TWO GROUPS: LATENT AUTOIMMUNE DIABETES IN ADULTS AND TYPE 2 DIABETES
Author: Gerond Husi, Matilda Kelmendi, Violeta Hoxha, Elizana Petrela, Adela Haxhiraj, Agron Ylli
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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