Abstract: The most common diabetes mellitus is type two diabetes mellitus (T2D). Type II diabetes mellitus exhibits chronic hyperglycemia and is thought to result from the progressive failure of pancreatic β-cells that do not secrete enough insulin to meet metabolic needs. Curcumin content in turmeric has been studied and used as an antioxidant, antiviral, anti-inflammatory, antifungal, liver protection, gastrointestinal effects, dissolving gallstones, anticarcinogenic, antimicrobial, cardiovascular, and others. This study aims to test the pancreoprotective activity of turmeric ethanol extract (EEK) in experimental animals by measuring biochemical parameters of temporary blood sugar levels, HbA1c, and amylase enzyme. This type of research is practical and was conducted in March 2022. This research was conducted at the Pharmacy Laboratory of the University of North Sumatra, Medan. A total of 24 male white Wistar rats (Rattus norvegicus) were purchased from the Medan Bintang street animal market. The results of the phytochemical screening of turmeric ethanol extract showed the presence of flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids—phytochemical screening results. The administration of turmeric ethanol extract showed a decrease in blood sugar levels which was inversely proportional to the increase in the dose of temulawak ethanol extract—the average HbA1c level of each treatment group. The lowest level in the standard group was 21.34 ± 0.66 ng/ml, and the highest level in the negative control group was 71.12 ± 3.44 ng/ml. Statistically, the negative control group had a significant difference (P<0.05) from the positive control group. This indicates that increasing the dose of turmeric ethanol extract can reduce HbA1c levels. The ethanol extract of turmeric reduces blood glucose levels, significantly different (P<0.05) from the negative control group, which was only given CMC-Na and doxorubicin. The turmeric extract at different doses had a very other HbA1c lowering activity (P<0.05) than the negative control group, which was only given CMC-Na and doxorubicin.
Keywords: turmeric, pancreas, doxorubicin.
Title: Exploration of the Effectiveness of Turmeric Ethanol Extract against the Enzyme Amylase Pancreas in Doxorubicin-Induced Wistar Rats
Author: Zhu Changwan
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 10, Issue 2, October 2022 - March 2023
Page No: 260-266
Research Publish Journals
Website: www.researchpublish.com
Published Date: 24-March-2023
